Cancer is the leading cause of death worldwide, accounting for nearly one in six deaths. In order to navigate the complex landscape of mutations and diverse types of genetic aberration that leads to cancer, the hallmarks of cancer were proposed as a set of functional capabilities acquired by human cells as normal cells transform into tumor cells in a multistage process that generally progresses from pre-cancerous lesion to a malignant tumor.

As cancer hallmarks have evolved over the last two decades so has our portfolio of tools to support cancer research. Over this time, we have called upon our diverse scientific and technical expertise to create innovative technologies, assays and reagents to aid with genomics, protein, cellular and tissue analysis, in addition to small molecules chemistry.

With our comprehensive catalog of unique products, we are committed to providing the tools and support you need to drive innovation and advancement in cancer and help discover the next hallmark.

Whether it's a specific gene, protein, lipids or a whole pathway, target identification is one of the most critical steps in cancer research and drug discovery.

AMPIVIEW™ RNA Probes

AMPIVIEW™ RNA probes are uniquely designed with the precision of targeted, sequence-specific RNA, powered by Enzo’s LoopRNA™ ISH technology to deliver superior sensitivity when combined with Enzo’s immunochemistry detection solutions. With sample morphology preserved, the spatial localization of target biomarkers can be visualized under the light microscope.

• Detection of unique nucleic acid targets (DNA/RNA or RNA) down to a single cell level
• High sensitivity and specificity
• Adaptable products ready for any workflow (Manual or Automated)

Genome instability and mutations are two of the most common causes of cancer. Fluorescence in situ hybridization (FISH) techniques provides a way to visualize and map the genetic material in individual cells. This is a very useful tool to understand a variety of chromosomal abnormalities and other genetic mutations.

DEEPSEE® CDKN2A/CEN3/7/17 Quad Probe Assay

Ready-to-use probes, used to detect the most frequently encountered chromosomal abnormalities in bladder cancer, contain fluorescently labeled nucleic acid targeting CDKN2A or p16 (gold) and three chromosomes, 3 (red), 7 (green) and 17 (aqua).

• Validated for use with cells and urine samples
• Ready-to-use probe mix to minimize pipetting errors
• Rapid detection of chromosomal aneuploidies and identification of loss

Some targets can play different roles depending on the cell type or microenvironment, hence, the characterization step is crucial for the understanding of the functional role that plays in normal cells vs cancer cells.

ROS-ID® Hypoxia/Oxidative Stress Detection Kit

ROS-ID® Hypoxia/Oxidative Stress Detection Kit is designed for functional detection of hypoxia and oxidative stress levels in live cells (both suspension and adherent) using fluorescent microscopy or flow cytometry.

• Detection of hypoxia with high sensitivity, selectivity and accuracy in cacer tissues and cells
• Allow for simple single-step detectin of hypoxia in non-fixed cells and tissues
• Dyes can be combined with ROS detection reagents for multiplexing

Understanding the roles of DNA damage repairs in the promotion of cancer is essential for the development of targeted cancer therapy.

Exposure of cells to oxidative and environmental stresses frequently results in the breakdown of genomic DNA.

DNA Damage ELISA Kit

The DNA Damage ELISA kit is a colometric competitive enzyme immnoassay kit that evaluates the integrity of genomic DNA by assessing the presence of oxidized DNA that are frequently used to verify the onset of apoptosis or DNA damage.

Rapid DNA Damage ELISA kit for cancer, apoptosis and oxidative stress.

• Reliable and validated in a variety of sample matrices
• Fully quantitative results that surpass semi-quantitative Western blot analysis
• No edge effect allowing to assay more samples per kit

Validation of the target is achieved with target analysis to understand and control its regulatory mechanism and the role that plays in the hallmarks of cancer.

Programmed cell death, such as apoptosis and autophagy, are regulated by a variety of biomacromolecures. Emerging evidence has revealed that programmed cell death are key features of tumorigenesis.

CYTO-ID® Autophagy Detection Kit 2.0

Monitor autophagy in live cells with CYTO-ID® Autophagy Detection Kit 2.0, which contains a brighter and more photostable dye that stains autophagic vesicles specifically.

• Rapid, no transfection required and only 30 minutes of incubation
• Negligible staining of lysosomes reduces background seen with other dyes
• Facilitates high-throughput screening of activators and inhibitors of autophagy

High quality biomarkers for cancer, especially antibodies, are crucial tools for prevention, diagnosis, prognostics, therapy and to effectively monitor treatment response after disease modifying treatments.

Enzo's portfolio of antibodies for cancer research includes thousands of monoclonal and polyclonal antibodies validated for various applications, including immunohistochemistry (IHC), immunofluorescence (IF), flow cytometry and Western blotting.

High Quality Antibodies for Cancer Research

Enzo offers an extensive repertoire of high-specificity antibodies for the study of cancer hallmarks, including predictive biomarkers such as p53, EGFR or p16.

• Rigorously validated in serveal applications
• Superb perfomance documented in thousands of peer-reviewed publications
• Backed by Enzo's Worry-free Antibody Trial Program

Leverage over 45 years of innovation and technical expertise supporting drug development, discovery, research, and diagnostics through our core technology platforms. With over 150,000 citations, GMP and ISO certifications, our highly-sensitive, quality products consistently deliver trusted results. We maintain product integrity and reliability with our in-house U.S. manufacturing facility. We deploy our bench of expert PhD scientists to provide technical, tailored, support for our customers and their projects.

Rely on our extensive experience in innovation, technology development, and manufacturing to support your cancer research and development. Our comprehensive Life Sciences Contract Services support the development of customizable, unique, and efficient solutions for all your research needs.

“ Our Technological Depth Enabling Efficiency for our Customers. “

Immuno-oncology, also known as cancer immunotherapy, refers to the use of a person’s own immune system for the treatment of cancer. Research in the field includes:

• Targeting immune tolerance via co-inhibitory immune checkpoints
• Enhancing immune responses by costimulatory checkpoint pathways

From Target Selection to Lead Profiling

Akt/PKB has emerged as a central player in the signal transduction pathways activated in response to growth factors or insulin. It is thought to contribute to several cellular functions including cell growth, transcriptional regulation, cell survival and nutrient metabolism. It has been linked to a range of diseases including cancer and type II diabetes.

The Akt/PKB pathway is a popular target since it sits at the crossroads of both oncogenic and tumor suppressor signaling pathways. Enzo provides novel tools to help support cancer discovery from target selection, hit-to-lead discovery, and lead profiling.

Novel Serine Protease Cancer Biomarker Products

Enzo Life Sciences offers more than 40 unique serine protease related products specifically related to cancer biomarker discovery, with emphasis on key family members identified as markers of early stage ovarian, breast, prostate and lung cancer.

• High-sensitivity, easy-to use and rapid ELISA kits
• Ready-to-user proteins for use as ELISA or Western blot standards
• Exclusive antibodies created against native proteins