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Innovation to Meet the Needs of Evolving Cancer Hallmarks

Your aim may be to investigate cancer’s genetic origins, establish the mechanism of action or clinical implications of tumor biomarkers, or develop a targeted pharmaceutical or cellular therapy. At Enzo, our aim is to support yours. As cancer hallmarks have evolved over the last decade, so has our portfolio of tools to support cancer research. Over this time, we have called upon our diverse scientific and technical expertise to create innovative assays and reagents in the fields of epigenetics, autophagy, and Wnt research. These novel tools, and a broad portfolio of products established for decades in peer-reviewed literature, will help support cancer discovery into the next decade, and beyond. We are continually focused on enabling a future with more hope, more collaboration, more discovery, and less disease.


Progress Begins With Research

Enzo is Engaged Against Cancer on Multiple Levels

Every year, Enzo sponsors the Walk for Beauty, organized by The Melville Heritage Organization.
All proceeds go to breast cancer research at Stony Brook Medicine. We're proud to support this initiative and can't wait for the 2021 Walk for Beauty!

As scientists enabling Healthcare, we are committed to providing a wide range of research tools to help reduce the global impact of cancer. Whether you investigate the genetic origins of cancer, study its underlying mechanism of action, or the role of tumor biomarkers and their implications in clinical diagnostics, Enzo is here to support your research.

Visualize the Spatial Biology of HPV under the Light Microscope


AMPIVIEW™ RNA probes are uniquely designed with the precision of targeted, sequence-specific RNA probes, powered by Enzo’s LoopRNA ISH™ technology to deliver superior sensitivity. Additionally, sample morphology in tissue specimen is preserved and the signal of the targeted biomarker can be seen under the light microscope.

  • High sensitivity and reliability with intense signal
  • Optimized with cost-effective IHC/ISH detection solutions
  • Flexible protocols for formalin-fixed, parafin-embedded (FFPE) tissues

High-Risk HPV detected with AMPIVIEW™ HPV High-Risk RNA probes signal (red) in cervical cancer tissue.

Low-Risk HPV detected with AMPIVIEW™ HPV 6/11 RNA probes (blue) in cervical tissue.


Unlock a 30% Discount*

Including new probes: GAPDH, EGFR, HPV 16/18, HPV 31/33/51, HPV 6/11, HPV High Risk, SARS-CoV-2, Ubiquitin, NORAD, Circ018, Nestin, Wnt5a

* Conditions apply.

Visualize cellular responses with high-specific, next-generation fluorescent dyes

CYTO-ID® Autophagy Detection Kit

A quantitative assay for monitoring autophagy in live cells

  • No transfection required
  • Proprietary dye stains autophagic vesicles with minimal lysosomal background
  • Protocol validated with known inhibitors and activators of autophagic activity

Quantify Autophagic Vesicles with Minimal Background

CYTO-ID® Green dye eliminates background staining of lysosomes seen with other lysosomotrophic dye-based assays that utilize monodansylcadaverine (MDC) (bottom panel). The CYTO-ID® Autophagy kit eliminates the need for a 350 nm UV laser for live cell analysis, and is compatible for use with Hoechst dyes for co-labeling in microscopy applications.

GFP-CERTIFIED® Apoptosis/Necrosis Detection Kit

Multiplex assay to distinguish between healthy, early apoptotic, late apoptotic, and necrotic cell

  • Specifically designed for use with GFP-expressing cell lines and cells expressing other fluorescent proteins (BFPs, CFPs)
  • Optimized for both fluorescence microscopy and flow cytometry applications
  • Suitable for use with live or post-fixed cells

Identify Different Stages of Apoptosis

A. Viable cells
B. Early apoptotic cells
C. Late apoptotic cells
D. Necrotic cells

Mitochondrial GFP-expressing HeLa cells were treated with 2µM Staurosporine for 4 hours. The Apoptosis Detection Reagent (Gold) and Necrosis Detection Reagent (Red) specifically detect cell states with clear spectral separation from mitochondria-associated GFP signal.

Measure Target Cell Subsets with Confidence

CD Marker Specific Antibodies

We offer primary antibodies for studying exploratory biomarkers in cancer research. Whether your research is focused on apoptosis, autophagy, metabolism, metastasis, proliferation, and inflammation, we have a broad selection of antibodies to help ensure your success.

  • Dependable, high quality antibodies for analyzing the hallmarks of cancer
  • Validated for multiple applications
  • Custom conjugation available

Cluster of Differentiation Marker-Specific Antibodies


Gene Expression & Copy Number Detection

Solutions for aCGH Analysis

Array-based comparative genomic hybridization (aCGH) is a powerful platform for detecting DNA copy number gains and losses associated with chromosomal abnormalities in genetic diseases and cancers. The proprietary labeling technology and high-performance dyes incorporated into our aCGH kits enhance performance with commonly implemented microarray platforms.

CYTAG® SuperCGH Labeling Kit

  • Validated for blood, amniotic fluid, postnatal, and oncology samples
  • Label low input samples, providing excellent dynamic analytical range down to 50 ng
  • Shorter workflow has samples ready for hybridization in < 4

Lowest DLR Scores for Low Input Samples

Comparative analysis of 50 ng DNA samples labeled with CYTAG® SuperCGH Labeling Kit or that of a leading competitor demonstrates significantly lower DLR scores.


Cancer Inhibitor Screening

Enzo Life Sciences offers the SCREEN-WELL® Cancer Library, a collection of 275 compounds that can be used for screening and assay development. The library contains small molecule inhibitors that affect mTOR, aurora kinases, tyrosine kinases, PI3K, and HDAC, as well as many other structurally and mechanically different compound classes. The SCREEN-WELL® Cancer Library is an essential tool for drug development and cancer inhibitor screening.


Akt Pathway Discovery

From Target Selection to Lead Profiling

Akt/PKB has emerged as a central player in the signal transduction pathways activated in response to growth factors or insulin. It is thought to contribute to several cellular functions including cell growth, transcriptional regulation, cell survival and nutrient metabolism. It has been linked to a range of diseases including cancer and type II diabetes.

The Akt/PKB pathway is a popular target since it sits at the crossroads of both oncogenic and tumor suppressor signaling pathways. Enzo provides novel tools to help support cancer discovery from target selection, hit-to-lead discovery, and lead profiling.


Serine Proteases and Cancer

Novel Serine Protease Cancer Biomarker Products

Enzo Life Sciences offers more than 40 unique serine protease related products specifically related to cancer biomarker discovery, with emphasis on key family members identified as markers of early stage ovarian, breast, prostate and lung cancer.

  • High-sensitivity, easy-to use and rapid ELISA kits
  • Ready-to-user proteins for use as ELISA or Western blot standards
  • Exclusive antibodies created against native proteins


Discover the next cancer breakthrough…

  • Modulate with high-purity small molecules & active proteins
  • Label with proprietary DNA & RNA amplification & labeling technologies
  • Detect with sensitive, widely-published biomarker ELISAs, antibodies & cell-based assays

Wnt Pathway Analysis


Cell Cycle Analysis

Monitor Adipokine &
Insulin Signaling

Oxidative Stress & DNA Damage
Quantify Critical Markers of Cellular Stress

Programmed Cell Death
Monitor Cell Fate & Quantify
Mediators of Death Pathways

Tumor Immunology
Define Innate & Adaptive
Anti-tumor Responses

Tumor Invasion & Angiogenesis
Detect and Screen Key Biomarkers
of Metastatic Potential

Oncogenic Signaling
Monitor Pro-growth Signals from Cell
Surface to Nucleus

Toxicity & Chemoresistance
Characterize Novel &
Repurposed Therapeutics

Gene Expression & Copy Number
Reveal Genomic Changes with High-fidelity
Nucleic Acid Labeling

Epigenetic Regulation
Flexible Formats for HDAC
& Sirtuin Screening


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