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Predictive Toxicology

A multipronged approach

Our complete portfolio of toxicology products are ideal for those who work in either the micro or macro world. Discover all the tools needed to monitor cellular health and drug metabolism for early drug safety assessment. Our line of CELLESTIAL® fluorescent dyes and probes allow for in vitro monitoring of cellular health with dyes that are specific and highly stable. Are you profiling organ-specific toxicity? Try our SCREEN-WELL® compound libraries, with a diverse number of compounds that are ready-to-use and essential for toxicology screening and assay development.

Monitoring toxicology in the environment is also crucial, especially in the areas of water safety and the effects of pollutants on local wildlife. Many countries rely on drinking water regulations to protect the public from potential harmful contaminants. Our full list of microcystins are ideal for monitoring cyanobacterial toxins for water quality testing. Other contaminants can affect animal welfare, our highly sensitive hormone ELISAs can be used to monitor wildlife endocrinology such as stress monitoring and reproductive health.

Discover the right tools for your research.

Cellular Health

Drug Metabolism

Environmental Studies

Cellular Health

Visualize Toxic Events in vitro

Our panel of fluorescence-based live cell assays is designed to help assess the impact of toxic agents on overall cell function. Our assays and probes have been developed to produce dyes that are sensitive, specific, and convenient. This offers increased photostability, eliminating non-specific dye-associated artifacts to reduce false positives, and compatibility with common dyes and fluorescent markers for multiplexing analysis. Our dyes are optimized for the most demanding imaging applications which allows their versatility to be used on a number of different platforms including, microplate-based high content screening, flow cytometry, confocal microscopy, and wide-field fluorescence microscopy, where consistency and reproducibility are essential.

Aggresomal Response Cell Viability & Proliferation Drug-drug Interactions Genotoxic Stress
PROTEOSTAT® Aggresome Detection Kit NUCLEAR-ID® Cell Viability Reagents
NUCLEAR-ID® Cell Cycle Analysis Kits
CYTO-ID® Long-term Tracer Kits
EFLUXX-ID® Multidrug Resistance Assay Kit aCGH Labeling Kits
BIOARRAY RNA Expression Analysis Kits
DNA Damage (8-OHdG) ELISA

Mitochondrial Toxicity Oxidative Stress Phospholipidosis / Steatosis Programmed Cell Death
MITO-ID® Mitochondrial Function Assays Total ROS/Superoxide Detection Kits
ROS/RNS Detection Kit
NO Detection Kits
Heme Oxygenase ELISAs
LYSO-ID® Red Cytotoxicity Kit CYTO-ID® Autophagy Detection Kit
CELLESTIAL® Apoptosis/Necrosis Detection Kit
NUCLEAR-ID® Chromatin Condensation Kit
Cytochrome C, p53, Survivin, Bcl-2

Drug Metabolism

Profile Organ-Specific Toxicity

Discover our complete, ready to use SCREEN-WELL® libraries for nephrotoxicity, cardiotoxicity, hepatotoxicity, and hematopoietic toxicity. Each contains compounds with defined and diverse organ-associated toxicity profiles. A variety of structurally and mechanistically different compound classes is included, as well as non-toxic controls. Compounds are dissolved in DMSO at 10mM and aliquoted into deepwell plates at 100 or 500μl per well for easy sample preparation. Our SCREEN-WELL® libraries are useful for predictive toxicology screening, including high-content protocols.

Portfolio Highlight
Products for Kidney Injury and Nephrotoxicity

Enzo provides a variety of tools to detect markers of acute kidney injury, renal failure, and renal metabolism. These thoroughly validated, high-sensitivity kits are validated for a variety of species and samples types and are supported by antibodies and proteins to support biomarker detection and characterization.

NGAL (lipocalin-2) ELISA Kits
Creatinine Detection Kit
SCREEN-WELL® Nephrotoxicity library

Other Biomarkers of Toxicity

Environmental Studies

Monitoring Water Quality and Animal Welfare

The adverse side effects that environmental pollutants can have on wildlife is one that is strongly studied by biologist all around the world. These effects can compromise a species ability to reproduce, their overall health, and the stability of their surrounding ecosystem. Biologists are dedicated to understanding how wildlife species are exposed to these pollutants and how these pollutants affect the species over time.

Our portfolio of Microcystins and Wildlife Endocrinology products can be used to study how these pollutants are exposed by different species and how pollutants can affect a species hormone and stress levels

Portfolio Highlight
Microcystins: Toxins from Cyanobacteria

Cyanobacterial toxins have been shown to be hazardous to humans and animals via direct and indirect routes of exposure such as ingestion of and contact with contaminated water, vegetables, fish/shellfish and through irrigation practices. Microcystins (MCs) are the most commonly encountered cyanotoxins. Studies have also shown that MCs play a role in liver toxicity and possibly even stimulate the growth of cancer cells following exposure.

Wildlife Endcrinology

Delivering Non-invasive Solutions for Wildlife Care

With thousands of species each year listed as endangered or threatened, the work done by biologists around the world to understand and preserve animal health is never ending. Reproduction studies and stress are two of the most common concerns today, as each species has its unique set of challenges that affect the biology and stresses related to rescue efforts, rehabilitation, and mating.

Hormone analysis continues to be widely accepted for monitoring stress response and evaluating reproductive health on wildlife. Our portfolio offers a broad range of highly specific immunoassay kits that are ideal for monitoring stress, reproductive physiology, health and welfare, and survival of wildlife animals.

Enzo Partners with the ISWE and AZA to deliver best in class products

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