Our panel of fluorescence-based live cell assays is designed to help assess the impact of toxic agents on overall cell function. Our assays and probes have been developed to produce dyes that are sensitive, specific, and convenient. This offers increased photostability, eliminating non-specific dye-associated artifacts to reduce false positives, and compatibility with common dyes and fluorescent markers for multiplexing analysis. Our dyes are optimized for the most demanding imaging applications which allows their versatility to be used on a number of different platforms including, microplate-based high content screening, flow cytometry, confocal microscopy, and wide-field fluorescence microscopy, where consistency and reproducibility are essential.

Discover our complete, ready to use SCREEN-WELL® libraries for nephrotoxicity, cardiotoxicity, hepatotoxicity, and hematopoietic toxicity. Each contains compounds with defined and diverse organ-associated toxicity profiles. A variety of structurally and mechanistically different compound classes is included, as well as non-toxic controls. Compounds are dissolved in DMSO at 10mM and aliquoted into deepwell plates at 100 or 500μl per well for easy sample preparation. Our SCREEN-WELL® libraries are useful for predictive toxicology screening, including high-content protocols.

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Products for Kidney Injury and Nephrotoxicity

Enzo provides a variety of tools to detect markers of acute kidney injury, renal failure, and renal metabolism. These thoroughly validated, high-sensitivity kits are validated for a variety of species and samples types and are supported by antibodies and proteins to support biomarker detection and characterization.

The adverse side effects that environmental pollutants can have on wildlife is one that is strongly studied by biologist all around the world. These effects can compromise a species ability to reproduce, their overall health, and the stability of their surrounding ecosystem. Biologists are dedicated to understanding how wildlife species are exposed to these pollutants and how these pollutants affect the species over time.

Our portfolio of Microcystins and Wildlife Endocrinology products can be used to study how these pollutants are exposed by different species and how pollutants can affect a species hormone and stress levels

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Microcystins: Toxins from Cyanobacteria

Cyanobacterial toxins have been shown to be hazardous to humans and animals via direct and indirect routes of exposure such as ingestion of and contact with contaminated water, vegetables, fish/shellfish and through irrigation practices. Microcystins (MCs) are the most commonly encountered cyanotoxins. Studies have also shown that MCs play a role in liver toxicity and possibly even stimulate the growth of cancer cells following exposure.

With thousands of species each year listed as endangered or threatened, the work done by biologists around the world to understand and preserve animal health is never ending. Reproduction studies and stress are two of the most common concerns today, as each species has its unique set of challenges that affect the biology and stresses related to rescue efforts, rehabilitation, and mating.

Hormone analysis continues to be widely accepted for monitoring stress response and evaluating reproductive health on wildlife. Our portfolio offers a broad range of highly specific immunoassay kits that are ideal for monitoring stress, reproductive physiology, health and welfare, and survival of wildlife animals.