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Mitigating Risk in Drug Development

Make it to the Market Faster - Solutions for Any Workflow


The study of chemical effects on biological processes has been a cornerstone of drug safety assessment. For decades, animal-based toxicology studies have been a significant source of information for determining drug risk assessment. Toxicity endpoints studies have produced evidence of potential organ and cell toxicities and mechanistic insight into a drug's activity. The drug design process requires early recognition of potentially toxic molecules to allow for redesign and optimization, ultimately leading to lower attrition rates and saved money. Hepatotoxicity, along with cardiotoxicity, are major causes of toxicity-related failures during the drug development process. New regulatory policies and the recent emphasis on animal-free toxicology studies have driven the field towards newer alternative methods such as in silico approaches and in vitro based studies. As in vitro technologies such as primary 3D cultures, organoids, and spheroids are becoming more common; the need to identify cytotoxicity across several platforms is gaining importance.

Download Our Predictive Toxicology Brochure


Visualize Toxic Events In Vitro

Reduce the risk of your drug discovery pipeline with our cell-based assays, assay kits, and reagents for mechanism and pathway analysis and biomarker detection. Enzo’s broad range of scientific expertise and industry-proven manufacturing capabilities provides a comprehensive set of solutions for the toxicology market when determining genotoxicity, membrane integrity, autophagy, and oxidative stress.



Cellestial® Live Cell Analysis Dyes

Illuminate your results with our high-specificity, next-generation fluorescent dyes for visualizing cellular responses and our complete collection of gold standard dyes.

We Have your in vitro Toxicology Solutions

In vitro studies help to clarify absorption, distribution, metabolism, and excretion (ADME) properties and can inform preclinical and clinical studies while facilitating go/no-go decisions. Our expertise and industry-proven capabilities provide solutions so you hit your drug discovery target.



Apoptosis/Necrosis Cardiotoxicity Endocrine Dysfunction


Genotoxicity Hepatotoxicity Mitochondrial Toxicity


Nephrotoxicity Oxidative Stress More Drug Discovery Solutions…
Bioprocess

Drug Discovery

Vaccines

Personal Care

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SCREEN-WELL® Toxicity Libraries

Compounds with defined and diverse organ-associated toxicity profiles. A variety of structurally and mechanistically different compound classes is included, as well as non-toxic controls. Compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates at 100 or 500 μl per well. The libraries are helpful for predictive toxicology screening, including high-content protocols.



PRODUCTS MAJOR TOXICITY CATEGORIES
Cardiotoxicity Library 130 compounds covering: Ion channel blockage, cardiomyocyte apoptosis, mitochondrial toxicity, thrombosis, arrhythmia, hypotension/hypertension, fibrosis & carditis, non-cardiotoxic controls
Hepatotoxicity Library 238 compounds covering: Steatosis, cholestatic effects, mitochondrial toxicity, CYP450 inactivation, toxic metabolites, Mallory body formation, elevation of liver enzymes, non-hepatotoxic controls
Hematopoietic Toxicity Library 115 compounds covering: Myelosuppression, leukopenia, neutropenia, anemia, thrombocytopenia, hematopoietically non-toxic controls
Nephrotoxicity Library 86 compounds covering: Analgesic nephropathy, interstitial nephritis, glomerulopathy, proximal and distal tubulopathy, nephrogenic diabetes insipidus, acute renal failure, chronic kidney disease, non-nephrotoxic controls
Myotoxicity Library 60 compounds covering: Myalgia, colchicine-induced myopathy, rhabdomyolysis, atrophy, necrosis, thrombocytopenia, non-myotoxic controls

Other In Vivo Toxicology Solutions

Enzo Life Sciences offers thousands of in vivo testing solutions, from ELISA kits suitable for various sample types to antibodies for specific biomarker detection. As scientists, we understand the critical nature of your results. With over 40 years of development and manufacturing expertise, you can have confidence in the reproducibility of your results lot after lot.



PRODUCTS MAJOR TOXICITY CATEGORIES
ELISA Kits Our portfolio of over 300 ELISA and detection kits include sensitive and specific assays for relevant markers of cell viability, signaling pathways, and organ-specific toxicity.
Activity Assays Understand drug-induced activity with our drug discovery kits, including COX activity, DPPIV, HDACs, and calcineurin.
Antibodies With over 3000 antibodies, Enzo has antibodies for biomarker expression, target validation, and tissue cross-reactive studies.
Proteins &
Enzymes
Enzo Life Sciences offers more than 1000 native and recombinant proteins, enzymes, antigens, and toxins. Our 45 year history of experienced manufacturing results in consistent and dependable lot-to-lot performance.

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