Reduce the risk of your drug discovery pipeline with our cell-based assays, assay kits, and reagents for mechanism and pathway analysis and biomarker detection. Enzo’s broad range of scientific expertise and industry-proven manufacturing capabilities provides a comprehensive set of solutions for the toxicology market when determining genotoxicity, membrane integrity, autophagy, and oxidative stress.
Illuminate your results with our high-specificity, next-generation fluorescent dyes for visualizing cellular responses and our complete collection of gold standard dyes.
In vitro studies help to clarify absorption, distribution, metabolism, and excretion (ADME) properties and can inform preclinical and clinical studies while facilitating go/no-go decisions. Our expertise and industry-proven capabilities provide solutions so you hit your drug discovery target.
| Apoptosis/Necrosis | Cardiotoxicity | Endocrine Dysfunction | ||
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| Genotoxicity | Hepatotoxicity | Mitochondrial Toxicity | ||
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| Nephrotoxicity | Oxidative Stress | More Drug Discovery Solutions… | ||
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Bioprocess Drug Discovery Vaccines Personal Care |
Target Discovery
CGH
Epigenetics
Small Molecule Libraries
Lead Generation & Refinement
Bioprocess (Upstream)
Clinical Development
CGH
Epigenetics
IHC
ISH / FISH
Bioprocess (Downstream)
Target Validation
IHC
ISH / FISH
Preclinical Development
CGH
Epigenetics
IHC
ISH / FISH
Compounds with defined and diverse organ-associated toxicity profiles. A variety of structurally and mechanistically different compound classes is included, as well as non-toxic controls. Compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates at 100 or 500 μl per well. The libraries are helpful for predictive toxicology screening, including high-content protocols.
| PRODUCTS | MAJOR TOXICITY CATEGORIES |
| Cardiotoxicity Library | 130 compounds covering: Ion channel blockage, cardiomyocyte apoptosis, mitochondrial toxicity, thrombosis, arrhythmia, hypotension/hypertension, fibrosis & carditis, non-cardiotoxic controls |
| Hepatotoxicity Library | 238 compounds covering: Steatosis, cholestatic effects, mitochondrial toxicity, CYP450 inactivation, toxic metabolites, Mallory body formation, elevation of liver enzymes, non-hepatotoxic controls |
| Hematopoietic Toxicity Library | 115 compounds covering: Myelosuppression, leukopenia, neutropenia, anemia, thrombocytopenia, hematopoietically non-toxic controls |
| Nephrotoxicity Library | 86 compounds covering: Analgesic nephropathy, interstitial nephritis, glomerulopathy, proximal and distal tubulopathy, nephrogenic diabetes insipidus, acute renal failure, chronic kidney disease, non-nephrotoxic controls |
| Myotoxicity Library | 60 compounds covering: Myalgia, colchicine-induced myopathy, rhabdomyolysis, atrophy, necrosis, thrombocytopenia, non-myotoxic controls |
Enzo Life Sciences offers thousands of in vivo testing solutions, from ELISA kits suitable for various sample types to antibodies for specific biomarker detection. As scientists, we understand the critical nature of your results. With over 40 years of development and manufacturing expertise, you can have confidence in the reproducibility of your results lot after lot.
| PRODUCTS | MAJOR TOXICITY CATEGORIES |
| ELISA Kits | Our portfolio of over 300 ELISA and detection kits include sensitive and specific assays for relevant markers of cell viability, signaling pathways, and organ-specific toxicity. |
| Activity Assays | Understand drug-induced activity with our drug discovery kits, including COX activity, DPPIV, HDACs, and calcineurin. |
| Antibodies | With over 3000 antibodies, Enzo has antibodies for biomarker expression, target validation, and tissue cross-reactive studies. |
| Proteins & Enzymes |
Enzo Life Sciences offers more than 1000 native and recombinant proteins, enzymes, antigens, and toxins. Our 45 year history of experienced manufacturing results in consistent and dependable lot-to-lot performance. |
