The SCREEN-WELL® Autophagy library contains 94 compounds with defined autophagy-inducing or -inhibitory activity. Compounds are dissolved in DMSO at 10mM or 1mM and aliquoted into deep-well plates at 100 or 500µl per well. A variety of structurally and mechanistically different compound classes are included. A useful tool for studying the roles of pro- and anti-autophagic molecules in cells as well as for use in in vitro applications.
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Product Literature References
Evaluation of autophagy inducers in epithelial cells carrying the ΔF508 mutation of the cystic fibrosis transmembrane conductance regulator CFTR: S. Zhang, et al.; Cell Death Dis.
9, 191 (2018),
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Loperamide, pimozide, and STF-62247 trigger autophagy-dependent cell death in glioblastoma cells: S. Zielke, et al.; Cell Death Dis.
9, 994 (2018),
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The Oxysterol 7-Ketocholesterol Reduces Zika Virus Titers in Vero Cells and Human Neurons: K.A. Willard, et al.; Viruses
11, 20 (2018),
Application(s): Vero and C6/36 cells ,
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Trans-Fats Inhibit Autophagy Induced by Saturated Fatty Acids: A. Sauvet, et al.; EBioMedicine
30, 261-272 (2018),
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ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect: H. Zinecker, et al.; Oncotarget.
8, 106764 (2017),
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Screening for small molecule inhibitors of statin-induced APP C-terminal toxic fragment production: K.S. Poksay, et al.; Front. Pharmacol.
8, 46 (2017),
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Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury: S. Martens, et al.; Cell Death Dis.
8, e2904 (2017),
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Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia: C.J. Holler, et al.; Mol. Neurodegener.
11, 46 (2016),
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An inverse small molecule screen to design a chemically defined medium supporting long-term growth of Drosophila cell lines: M. Burnette, et al.; Mol. Biosyst.
10, 2713 (2014),
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