The SCREEN-WELL® Nephrotoxicity Library is a focused collection of 86 compounds with defined and diverse nephrotoxicity, including analgesic nephropathy, interstitial nephritis, glomerularopathy, proximal and distal tubulopathy, acute renal failure, chronic kidney disease, and more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. Most of the compounds are dissolved in DMSO at 10mM unless otherwise stated in the documentation provided with the library. Selected compounds are dissolved in DI water. All compounds are provided at 100 µl volumes in a 96-well plate. This library is an essential cost-effective tool for predictive toxicology screening and assay development.
Product Details
Applications:
HTS
Contents:
86 compounds with defined and diverse nephrotoxicity. A variety of structurally and mechanistically different compound classes, as well as nontoxic controls, are included.
Quantity:
100 µl/well
Concentration:
Solvent and concentration are specified in the documentation provided with the library.
Use/Stability:
Stable for at least one year from the date of receipt when stored at -80°C.
Handling:
Avoid freeze/thaw cycles.
Shipping:
Dry Ice
Long Term Storage:
-80°C
Technical Info/Product Notes:
Regulatory Status:
RUO - Research Use Only
Product Literature References
A high-throughput screening assay to identify kidney toxic compounds: S. Ramm, et al.; Curr. Protoc. Toxicol. 69, 9.10.1 (2016), Abstract;
Ultra sensitive (1.279 pg/ml) ELISA kit, enabling reduced input sample and matrix interference, for the quantification of KIM-1, an early biomarker for kidney injury or disease.
