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SCREEN-WELL^® Hepatotoxicity library

Essential standards for predictive toxicology screening



BML-2851-0500	1 Library	500 µl/well	Inquire for pricing

BML-2851-0100	1 Library	100 µl/well	Inquire for pricing
Do you need bulk/larger quantities?

The SCREEN-WELL^® Hepatotoxicity Library is a focused collection of 238 compounds with defined and diverse hepatotoxicity, including steatosis, mitochondrial toxicity, Mallory body formation, cholestatic effects, and many more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. The compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates. The library is an essential tool for predictive toxicology screening and assay development.

Product Specification

Applications:	HTS

Contents:	238 compounds with defined and diverse hepatotoxicity. A variety of structurally and mechanistically different compound classes, as well as nontoxic controls, are included.

Quantity:	100 µl/well or 500 µl/well

Concentration:	DMSO solutions (10mM).

Use/Stability:	Stable for at least one year from the date of receipt when stored at -80°C.

Handling:	Avoid freeze/thaw cycles.

Shipping:	Shipped on Dry Ice

Long Term Storage:	-80°C

Technical Info/Product Notes:	Application Note (Predictive Toxicology Application): Predictive High-Content/High-Throughput Assays for Hepatotoxicity Using Induced Pluripotent Stem Cell (iPSC)-Derived Hepatocytes. Three Dimensional Hepatotoxicity Screening using Corning® HepatoCells, the Spheroid Microplate, and the SCREEN-WELL® Hepatotoxicity Library.

Regulatory Status:	RUO - Research Use Only

Product Literature References

Live‐cell screening platform using human‐induced pluripotent stem cells expressing fluorescence‐tagged cytochrome P450 1A1: J.W. Kim, et al.; FASEB J. 34, 9141 (2020), Abstract;

Stem-cell derived hepatocyte-like cells for the assessment of drug-induced liver injury: M.T. Donato, et al.; Differentiation 106, 15 (2019), Abstract;

High-Content Assays for Hepatotoxicity Using Induced Pluripotent Stem Cell-Derived Cells: O. Sirenko, et al.; Assay Drug Dev. Technol. 12, 43 (2014), Abstract; Full Text