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SCREEN-WELL® Hepatotoxicity library

Essential standards for predictive toxicology screening
BML-2851-0100 1 Library 100 µl/well 4,465.00 USD
BML-2851-0500 1 Library 500 µl/well 13,447.00 USD
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The SCREEN-WELL® Hepatotoxicity Library is a focused collection of 238 compounds with defined and diverse hepatotoxicity, including steatosis, mitochondrial toxicity, Mallory body formation, cholestatic effects, and many more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. The compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates. The library is an essential tool for predictive toxicology screening and assay development.

Product Details

Contents:238 compounds with defined and diverse hepatotoxicity. A variety of structurally and mechanistically different compound classes, as well as nontoxic controls, are included.
Quantity:100 µl/well or 500 µl/well
Concentration:DMSO solutions (10mM).
Use/Stability:Stable for at least one year from the date of receipt when stored at -80°C.
Handling:Avoid freeze/thaw cycles.
Shipping:Dry Ice
Long Term Storage:-80°C
Technical Info/Product Notes:

Application Note (Predictive Toxicology Application):
Predictive High-Content/High-Throughput Assays for Hepatotoxicity Using Induced Pluripotent Stem Cell (iPSC)-Derived Hepatocytes.
Three Dimensional Hepatotoxicity Screening using Corning® HepatoCells, the Spheroid Microplate, and the SCREEN-WELL® Hepatotoxicity Library.
Regulatory Status:RUO - Research Use Only

Product Literature References

A 3D microfluidic liver model for high throughput compound toxicity screening in the OrganoPlate®: K.M. Bircsak, et al.; Toxicology 450, 152667 (2021), Abstract;
High-fidelity drug-induced liver injury screen using human pluripotent stem cell–derived organoids: T. Shinozawa, et al.; Gastroenterology. 160, 831 (2021), Abstract; Full Text
Live‐cell screening platform using human‐induced pluripotent stem cells expressing fluorescence‐tagged cytochrome P450 1A1: J.W. Kim, et al.; FASEB J. 34, 9141 (2020), Abstract;
Stem-cell derived hepatocyte-like cells for the assessment of drug-induced liver injury: M.T. Donato, et al.; Differentiation 106, 15 (2019), Abstract;
The convergence of stem cell technologies and phenotypic drug discovery: A. Friese, et al.; Cell Chem. Biol. 26, 1050 (2019), Abstract;
High-Content Assays for Hepatotoxicity Using Induced Pluripotent Stem Cell-Derived Cells: O. Sirenko, et al.; Assay Drug Dev. Technol. 12, 43 (2014), Abstract; Full Text

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