Cell Death
Enzo provides a variety of tools to detect the onset of cell death pathways, including sensitive fluorescent probes for detection of apoptosis, necrosis, and autophagy. These assays can help detect subtle changes in the health of adherent or suspension cell cultures used for production of biotherapeutics, and assess toxicity during drug development.
Autophagy and Apoptosis Assays
|
Oxidative Stress
Changes in mitochondrial function and glucose metabolism can adversely affect cell line viability, decreasing protein yield in cultured cells and long-term efficacy of cell based therapies. Enzo provides an industry-leading portfolio of kits and reagents for monitoring oxidative stress, including sensitive, high-throughput compatible assays for hypoxia, reactive oxygen species (ROS) and mitochondrial dysfunction.
High-throughput analysis of mitotoxicity
|
Cell Line Instability
Changes in gene expression due to endogenous or transgene copy number loss, or epigenetic suppression can affect cell line stability and yield. Our portfolio of products for detection of cell line instability include fluorescent labeling kits for high-resolution array CGH, RNA amplification and labeling, and DNA methylation.
Superior dye incorporation results in more accurate detection
|