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Caspase-3 inhibitor
ALX-260-030-M001 1 mg 79.00 USD
ALX-260-030-M005 5 mg 304.00 USD
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Replaces Prod. #: BML-P410

Highly specific, potent and reversible inhibitor of caspase-3. Ki<1nM for purified caspase-3. IC50=0.2nM for PARP cleavage in cultured human osteosarcoma cell extracts. In contrast, the caspase-1 (ICE) specific inhibitor YVAD-CHO has a Ki=12µM for caspase-3 and IC50>10µM for PARP cleavage in osteosarcoma cell extracts. The DEVD sequence is based on PARP cleavage site Asp-216 for caspase-3.

Product Details

Alternative Name:Caspase-3 inhibitor (aldehyde), Caspase-7 inhibitor (aldehyde)
Peptide Content:70-90%.
Purity:≥95% (HPLC)
Solubility:Soluble in distilled water or DMSO.
Reconstitution:Add 0.2ml DMSO per 1mg peptide. Shake well until all the contents are dissolved. This furnishes a 10mM solution of this material.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Stock solutions should be divided into aliquots and stored at -20°C. Solutions are stable for at least 1 month when stored at -20°C in the dark and protected from moisture.
Handling:Keep under nitrogen. Keep cool and dry.
Regulatory Status:RUO - Research Use Only

Product Literature References

Hydrogen Peroxide Is Crucial for NLRP3 Inflammasome-Mediated IL-1β Production and Cell Death in Pneumococcal Infections of Bronchial Epithelial Cells; Journal of Innate Immunity: S. Surabhi, et al.; J. Innate Immun. 10, 1159 (2021), Abstract;
Promoted "Click" SERS Detection for Precise Intracellular Imaging of Caspase-3: W. Zhu, et al.; Anal. Chem. 93, 4876 (2021), Abstract;
Activation of NLRP3 by uropathogenic Escherichia coli is associated with IL-1β release and regulation of antimicrobial properties in human neutrophils: I. Demirel, et al.; Sci. Rep. 10, 21837 (2020), Abstract; Full Text
The Therapeutic Value of SC66 in Human Renal Cell Carcinoma Cells: M. Xu, et al.; Cell Death Dis. 11, 353 (2020), Abstract; Full Text
Curcumin differentially affects cell cycle and cell death in acute and chronic myeloid leukemia cells: M. Martinez-Castillo, et al.; Oncol. Lett. 15, 6777 (2018), Abstract; Full Text
Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding: K.B. Dagbay, et al.; J. Biol. Chem. 292, 4885 (2017), Abstract; Full Text
Albumin-binding caspase-cleavable prodrug that is selectively activated in radiation exposed local tumor: S.W. Chung, et al.; Biomaterials 94, 1 (2016), Application(s): Cell culture, Abstract;
Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts: R. Ghosh, et al.; Int. J. Cardiol. 223, 923 (2016), Application(s): Measurement of Caspase 3 activity - mouse heart, liver, and kidney, Abstract;
MicroRNAs in Hyperglycemia Induced Endothelial Cell Dysfunction: M. Silambarasan, et al.; Int. J. Mol. Sci. 17, 518 (2016), Application(s): Cell culture, Abstract; Full Text
Differential apoptosis-related protein expression, mitochondrial properties, proteolytic enzyme activity, and DNA fragmentation between skeletal muscles: E.M. McMillan, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 300, R531 (2011), Abstract; Full Text
Inhibition of ubiquitin-proteasome pathway activates a caspase-3-like protease and induces Bcl-2 cleavage in human M-07e leukaemic cells: X.M. Zhang, et al.; Biochem. J. 340, 127 (1999), Abstract; Full Text
Interferon gamma induces upregulation and activation of caspases 1, 3, and 8 to produce apoptosis in human erythroid progenitor cells: C. Dai & S.B. Krantz; Blood 93, 3309 (1999), Abstract;
Inhibition of human caspases by peptide-based and macromolecular inhibitors: M. Garcia-Calvo, et al.; J. Biol. Chem. 273, 32608 (1998), Abstract; Full Text
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro: Z. Han, et al.; J. Biol. Chem. 272, 13432 (1997), Abstract; Full Text
CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis: J. Schlegel, et al.; J. Biol. Chem. 271, 1841 (1996), Abstract; Full Text
ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis: D.W. Nicholson; Nature Biotechnol. 14, 297 (1996), Abstract;
Sequential activation of ICE-like and CPP32-like proteases during Fas- mediated apoptosis: M. Enari, et al.; Nature 380, 723 (1996), Abstract;
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis: D.W. Nicholson, et al.; Nature 376, 37 (1995), Abstract;
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE: Y.A. Lazebnik et al.; Nature 371, 346 (1994), Abstract;

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