Modulation of Glucose & Lipid Metabolism

Recombinant Human Adiponectin

HMW Adiponectin Delivering Superior In Vitro Activity

Quantify Adiponectin

Adiponectin (human), ELISA Kit

A Rapid, High-sensitivity ELISA Kit for Quantification of Human Adiponectin

Adiponectin Receptor Activation

AdipoRon

A Novel Small Molecule Adiponectin Mimetic

Proinsulin and Insulin Secretion

Insulin ELISA kit

Highly sensitive Insulin ELISA kit enabling detection of insulin in serum, plasma, tissue culture media in just 3 hours.

Proinsulin ELISA kit

Ultra-sensitive Proinsulin ELISA kit enabling detection of proinsulin in human serum and plasma samples in just 3 hours.

Leptin Sensitivity

Leptin (mouse), (recombinant)

[pTyr⁷⁰⁵]STAT3 monoclonal antibody (9E12)

c-Fos polyclonal antibody

Diabetes / Obesity Modulators

PPAR Agonists

PPAR Antagonist

AMPK

Antidiabetic Agents

Modulators of Browning

Irisin (human), (recombinant) (active)

PPAR Ligands

Adipokines

Adrenergic Agonists

Adipogenesis Dye Allows for Visual Confirmation of Adipocyte Differentiation



3T3-L1 cells were treated with and without induction media. After 10 days, cells were stained with Adipogenesis Dye and imaged at 40x magnification.

GLP and Exendin

GLP (glucagon-like peptide) functions in the regulation of blood glucose through insulin, and plays a role in obesity and diabetes. GLP-1 is an important gastrointestinal peptide hormone or incretin, which is released when we eat, produced by tissue specific post-translational processing from a glucagon precursor, and inactivated by dipeptidylpeptidase DPP-4 enzymes. Exendin-4 is a 39 amino-acid peptide found in venom from the Gila monster. It is a member of the glucagon-secretin family of peptide hormones and neuropeptides. As an agonist of the GLP-1 receptor, Exendin-4 is a potent stimulator of insulin secretion and has a much longer half life than GLP-1 (~2 minutes) making it a suitable drug candidate for the treatment of obesity and type-2 diabetes.

• AMP’D® GLP-1 ELISA Kit
• GLP Antibodies
• Exendin Antibodies
• GLP Proteins
• Exendin-4 Protein

Lipocalin-2, Neutrophil Gelatinase-associated Lipocalin (NGAL)

NGAL (also known as Lipocalin-2 or Neutrophil Gelatinase-associated Lipocalin) is a small, ~25kDa secreted protein expressed in epithelial tissues and released into both urine and blood upon kidney tubular damage. The protein is protease resistant and over-expressed during inflammation, infection and certain cancers. During acute renal failure (ARF) caused by either ischemia or nephrotoxicity, NGAL is secreted in high levels into blood and urine within 2 hours or less of injury to the kidney. NGAL is also released at the time of acute kidney injury (AKI) unlike serum creatinine, another kidney diagnostic biomarker which may not be seen until 72 hours after injury when up to 50% of renal function may have been lost.

• NGAL ELISA Kits
• NGAL Antibodies
• NGAL Proteins

Adipokines

Adipose tissue contains differentiated cells called adipocytes that are specialized in storing fat. In addition to their function in controlling energy homeostasis, adipocytes release endocrine and paracrine signaling molecules called adipokines that are important in many physiological and metabolic processes. Some adipokines such as adiponectin, omentin, Nampt (Visfatin/PBEF), resistin or RBP4 are involved in insulin signaling. Others regulate food intake and lipid metabolism (e.g. leptin, chemerin).

Built upon our diverse scientific expertise and technology platforms, Enzo solutions enable you to advance your metabolic research with more than 250 ELISA kits for accurate detection of your specific analyte.