Soluble in DMSO (86mg/ml) or ethanol (50mg/ml). Slightly soluble in water (<1mg/ml).
Shipping:
Shipped on Blue Ice
Long Term Storage:
-20°C
Use/Stability:
Store, as supplied, up to 3 years at -20°C.
Scientific Background:
Produced by adipocytes, adiponectin has circulating levels that are inversely related to the degree of adiposity. Adiponectin concentrations correlate negatively with glucose, insulin, triglyceride concentrations, liver fat content and body mass index, while correlating positively with high-density lipoprotein-cholesterol levels, hepatic insulin sensitivity and insulin-stimulated glucose disposal. Adiponectin controls many metabolic processes and is known to contribute to metabolic pathologies including diabetes, atherosclerosis, and obesity. It has been shown to increase insulin sensitivity and decrease plasma glucose by increasing tissue fat oxidation. Adiponectin receptor activation is a promising potential therapy for diabetes and other obesity-associated diseases.
AdipoRon is a small-molecule adiponectin mimetic. At low micromolar concentrations, it binds to the adiponectin receptors AdipoR1 and AdipoR2. In addition, AdipoRon is orally administered and readily absorbed and delivered to target tissues, making it potentially clinically relevant. AdipoRon has been shown to induce insulin sensitivity, inhibit lipid synthesis and increase glucose metabolism.
Regulatory Status:
RUO - Research Use Only
Fig 1. AdipoRon and Adiponectin have similar downstream effects.
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Product Literature References
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity: M. Okada-Iwabu, et al.; Nature 503, 493 (2013), Abstract;
Cell Biology. Ronning after the adiponectin receptors: W.L. Holland, et. al.; Science 342, 1460 (2013), Abstract;
Homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity
Produced in HEK 293 cells. Mouse adiponectin (aa 18-247) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag., ≥90% (SDS-PAGE) | Print as PDF
Homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity
Produced in HEK 293 cells. Human adiponectin (aa 16-244) is fused at the N-terminus to a linker peptide (14 aa) and a FLAG®-tag., ≥90% (SDS-PAGE) | Print as PDF
