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Rhodamine 123 (ultra pure)

Mitochondria dye
ENZ-52307 25 mg 121.00 USD
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Replaces Prod. #: ALX-610-018

Rhodamine 123 is a cell-permeant, cationic, green-fluorescent dye that is readily sequestered by active mitochondria without cytotoxic effects. Rhodamine 123 can be used in multi-parametric analysis, without fluorescence interference, in combination with common protein labeling dyes such as cyanine-5 and AMCA. With respect to apoptosis, the presence of mitochondrial membrane potential can be probed with rhodamine 123 while the structure and integrity of mitochondria can be assessed using 10-N-nonyl-acridine orange. Wavelength Maxima: Excitation 507nm, Emission 529nm

Product Details

Alternative Name:3,6-Diamino-9-(2-(methoxycarbonyl)phenyl xanthylium chloride
Purity:≥95% (HPLC)
Solubility:Soluble in DMSO.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Stable for at least one year after receipt when stored as recommended.
Handling:Protect from light. Keep cool and dry.
Technical Info/Product Notes:This product is a member of the CELLESTIAL® product line, reagents and assay kits comprising fluorescent molecular probes that have been extensively benchmarked for live cell analysis applications. CELLESTIAL® reagents and kits are optimal for use in demanding imaging applications, such as confocal microscopy, flow cytometry and HCS, where consistency and reproducibility are required.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88-Dependent Inflammation: W. Luo, et al.; Adv. Sci. 9, 202202590 (2022), Abstract;
All layers matter: Innovative three-dimensional epithelium-stroma-endothelium intestinal model for reliable permeability outcomes: M.H. Macedo, et al.; J. Control Release 341, 414 (2021), Abstract;
Neuroprotective Effect of Cyclo-(L-Pro-L-Phe) Isolated from the Jellyfish-Derived Fungus Aspergillus flavus: D.D. Li, et al.; Mar. Drugs 19, 417 (2021), Abstract;
PDE2 regulates membrane potential, respiration and permeability transition of rodent subsarcolemmal cardiac mitochondria: D. Liu, et al.; Mitochondrion 47, 64 (2020), Abstract; Full Text
Detection of de- and hyperpolarization of mitochondria of cultured astrocytes and neurons by the cationic fluorescent dye rhodamine 123: S. Kahlert, et al.; J. Neurosci. Methods 171, 87 (2008), Abstract;
Assay for apoptosis using the mitochondrial probes, Rhodamine123 and 10-N-nonyl acridine orange: C. Ferlini & G. Scambia; Nat. Protoc. 2, 3111 (2007), Abstract;

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