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Enabling Solutions for Genomics Analysis

Enzo Life Sciences is a recognized pioneer and innovator of life sciences tools, backed by patented DNA and RNA labeling chemistries for genomics research and development. The pillar of our molecular biology portfolio is our comparative genomic hybridization (aCGH) kit, a powerful platform for detecting DNA copy number gains and losses associated with chromosome abnormalities. aCGH provides a greater understanding and characterization of genetic disorders, cancers, and other genomic aberrations.

Supporting our aCGH kits are a variety of everyday-use molecular biology products designed to maximize the quantity and quality of data generated from your valuable samples. These include RNA and DNA amplification kits, as well as labeling systems and modified nucleotides designed for creating biotin- or fluorophore-labeled nucleic acid probes for a variety of applications and detection platforms. The products have been specifically designed to provide optimal performance in nick translation reactions or with Agilent® arrays.

To further support your analysis of chromosomal and genomic structure Enzo Life Sciences provides all the materials needed (dye- or biotin-labeled nucleotides, nick translation kits, hybridization solutions and development chemistry) to generate the highest quality fluorescence or chromogenic in situ hybridizations experiments.


Next Generation Sequencing

Tools to Streamline Your NGS Workflow

Next generation sequencing (NGS) is a method of high-throughput sequencing in which millions of DNA strands can be sequenced in parallel. Many researchers use NGS as an important tool to gain insight into the detailed and comprehensive genetic and epigenetic modifications of genomes from many different cell types. Choose from our comprehensive mix of kits to extract and prepare your library sample for NGS analysis.

Whether you are preparing samples for ChIP-seq, whole genome sequencing, or Bisuilfite-sequencing our kits are easy, efficient, and convenient.

Microarray Labeling

Enable Proven, Consistent array CGH

CYTAG® CGH Labeling Kit

Array-based comparative genomic hybridization (aCGH) is a powerful tool for detecting gene copy number gains and losses associated with chromosome abnormalities. Detecting chromosomal aberrations by array CGH is faster, more robust and provides superior results over other technologies such as FISH and G-banding karyotyping, thus providing a greater understanding of the role of chromosomal changes in genetic diseases and cancers. Enzo superior labeling technology yields the industry’s most consistent CGH results.

CYTAG® TotalCGH Labeling Kit

For a complete solution to prepare DNA for CGH+SNP analysis, Enzo offers the CYTAG® TotalCGH Labeling Kit. Included in the kit are restriction enzymes AluI and RsaI for DNA digestion, the CYTAG® CGH Labeling kit for superior labeling, and PCR & Gel Clean-up columns for purifying labeled DNA.

CYTAG® SuperCGH Labeling Kit

Enzo is now offering CYTAG® SuperCGH Labeling Kits for producing high quality oligo array data using as little as 50 ng of genomic DNA, without a need for pre-amplification for precious low input samples. Validated for a wide range of low input samples including blood, amniotic fluid, postnatal and oncology samples, our CYTAG® SuperCGH Labeling Kit is your solution for labeling difficult samples.

Gene Expression and Transcript Analysis

BIOARRAY® Amplification & Labeling Kits

Enzo’s BIOARRAY® RNA Amplification & Labeling kits offer labeling solutions for biotin-based gene expression microarrays. Due to greater biotin incorporation and brighter signal, BIOARRAY® RNA labeling is the best choice for routine GeneChip® analysis.

Analyze Limiting Quantities of Total RNA

Don’t let the quantity of starting material limit your assay. Our BIOARRAY® Low Input RNA Amplification and Biotin Labeling System generates sufficient biotin labeled aRNA from as little as 20ng of total input RNA.

In situ Hybridization & FISH

PATHO-GENE® & BIOPROBE® Virus Detection Assays

PATHO-GENE® Human Papillomavirus in situ typing assays for sensitive detection of pathogen-expressed genes from fresh or FFPE tissue sections
The assays employ separate mixtures of biotin-labeled Human Papillomavirus (HPV)-specific probes to detect and identify HPV/DNA-infected biopsy tissue sections. The identifying probes are HPV types 6/11 (benign lesions), 16/18 (cervical intraepithelial neoplasia [CIN] and carcinoma in situ [CIS]), or 31/33/51 (condyloma or cervical intraepithelial neoplasia [CIN] and carcinoma in situ [CIS]).


Visualize the spatial biology of target genes with ease

AMPIVIEW™ RNA probes are uniquely designed with the precision of targeted, sequence specific RNA, powered by Enzo’s LoopRNA ISH™ technology to deliver superior sensitivity when combined with Enzo’s linkers and immunohistochemistry (IHC) detection solutions. When AMPIVIEW™ RNA probes hybridize to nucleic acid targets, loops form exposing biotin or digoxigenin labels, making these probes highly specific and sensitive to detect. Target genes can be visualized in its morphological context with a light microscope.


Labeling & Detection Systems

Digoxigenin Labeling & Detection
Digoxigenin NHS ester
Digoxigenin-dUTP, alkali-stable
Digoxigenin-UTP, alkali-stable
Digoxigenin polyclonal antibody

BIOPROBE® Labeling Systems
BIOPROBE® Nick Translation Systems
BIOPROBE® Random Primed Labeling Systems

Hybridization Reagents & Buffers

Detection Systems
SAVIEW® PLUS Detection System
POLYVIEW® PLUS detection system

FISH Solutions

Enzo offers fluorescent dye-dUTPs and Nick Translation DNA Labeling System for making FISH probes. This direct approach provides a simple and efficient method to label DNA for FISH, suitable for a wide range of molecular biology and cytogenetics applications.



AMPIPROBE® Nucleic Acid Detection

AMPIPROBE® incorporates Enzo’s proprietary primer design in a unique qPCR platform that enables sensitive detection of nucleic acids. AMPIPROBE® assay kits, a low-cost alternative in a price-sensitive market, are designed for clinically relevant targets. Enzo’s landmark AMPIPROBE® assay, the AMPIPROBE® HCV assay kit, is a sensitive qPCR assay to measure Hepatitis C viral load.

AMPIGENE® PCR and qPCR Solutions

Enzo offers solutions for both traditional PCR and qPCR. Our AMPIGENE® Taq Mixes and RT-PCR Kit are optimized for standard PCR experiments and come in a variety of flexible formats to enable easy PCR and RT-PCR. In addition, we offer AMPIGENE® qPCR Kits and Mixes for both dye-based and probe-based real-time PCR. Enhanced buffers with stabilizers prevent the formation of primers/dimers to ensure sensitive and specific results for your qPCR and RT-qPCR applications.

CYGREEN® Nucleic Acid Dye

CYGREEN® Nucleic acid dye can be used for gel staining, higher sensitivity qPCR, and melt curve analysis. It has excitation/emission spectra similar to commonly used qPCR dyes and can be substituted in to increase sensitivity and reduce cost.

Nucleic Acid Extraction and Purification

PCR & Gel clean-up columns

PCR & Gel clean-up columns use silica membrane technology in a mini spin column format to deliver easy and efficient DNA purification from PCR products, agarose gels, and labeling reactions.

  • High recoveries for fragments down to 50 bp
  • Small elution volume down to 15 µl
  • Binding buffer with pH indicator
  • Validated for use with CGH labeling kit

Related Literature and Documents

Related TechNotes

FISH Testing in Cancer
2019 March 29 | Tags: Cancer, Molecular Biology

FISHing for the right probe
2014 April 17 | Tags: Molecular Biology

New Products

AMPIVIEW™ NORAD (AS) Dig RNA Probes (Mouse) Set
A digoxigenin-labeled RNA probe for the in situ hybridization (ISH) detection lncRNA NORAD in mouse or rat cells and tissues
AMPIVIEW™ Wnt5a (AS) Dig RNA Probes (Rat) Set
A digoxigenin-labeled RNA probe for the in situ hybridization (ISH) detection Wnt5a in rat cells and tissues
AMPIVIEW™ Circ018 (AS) Dig RNA Probes (Mouse) Set
A digoxigenin-labeled RNA probe for the in situ hybridization (ISH) detection lncRNA Circ018 in mouse or rat cells and tissues
AMPIVIEW™ Nestin (AS) Dig RNA Probes (Rat) Set
A digoxigenin-labeled RNA probe for the in situ hybridization (ISH) detection Nestin in rat cells and tissues
AMPIVIEW™ Hybridization Buffer (1X)
Optimized buffer to use with Enzo's AMPIVIEW™ RNA probes

Featured Literature

Genomics & Molecular Biology
Human Papillomavirus - Clear Results, Innovative Solutions for HPV Detection

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