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United States 

AEBSF . hydrochloride

Serine protease inhibitor
ALX-270-022-M050 50 mg 63.00 USD
ALX-270-022-M250 250 mg 230.00 USD
ALX-270-022-G001 1 g 647.00 USD
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Specific irreversible inhibitor of serine proteases including trypsin, chymotrypsin, plasmin, plasma kallikrein, and thrombin. Stable, non-toxic alternative to PMSF (Prod. No. ALX-270-184). Inhibitor of NAD(P)H oxidase. Activator of MAP kinases JNK and p38.

Product Details

Alternative Name:4-(2-Aminoethyl)benzenesulfonylfluoride . HCl, Pefabloc®SC
Formula:C8H10FNO2S . HCl
Purity:≥98% (HPLC)
Appearance:White to off-white powder.
Solubility:Soluble in water or 100% ethanol.
Shipping:Ambient Temperature
Long Term Storage:+4°C
Handling:Protect from moisture and light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

UBQLN2 undergoes a reversible temperature-induced conformational switch that regulates binding with HSPA1B: ALS/FTD mutations cripple the switch but do not destroy HSPA1B binding: T.H. Phung, et al.; Biochim. Biophys. Acta Gen. Subj. 1867, 130284 (2023), Abstract;
Bifunctional hetero di-disc for broad-spectrum influenza neutralization: S. Moon, et al.; Nanomedicine 44, 102587 (2022), Abstract;
AMP-activated protein kinase Is activated by non-steroidal anti-inflammatory drugs: T.S. King, et al.; Eur. J. Pharmacol. 762, 299 (2015), Application(s): Western Blot, Abstract;
TANK-binding kinase 1 (TBK1) modulates inflammatory hyperalgesia by regulating MAP kinases and NF-κB dependent genes: C. V. Möser, et al.; J. Neuroinflammation 12, 100 (2015), Application(s): Western Blot, Abstract; Full Text
Inhibitory effect of 4-(2-aminoethyl)-benzenesulfonyl fluoride, a serine protease inhibitor, on PI3K inhibitor-induced CHOP expression: T. Hosoi, et al.; Eur. J. Pharmacol. 554, 8 (2007), Abstract;
Heme oxygenase-1 gene activation by the NAD(P)H oxidase inhibitor 4-(2-aminoethyl) benzenesulfonyl fluoride via a protein kinase B, p38-dependent signaling pathway in monocytes: N. Wijayanti, et al.; J. Biol. Chem. 280, 21820 (2005), Abstract; Full Text
Evaluation of two inhibitors of invasion: LY311727 [3-(3-acetamide-1-benzyl-2-ethyl-indolyl-5-oxy)propane phosphonic acid] and AEBSF [4-(2-aminoethyl)-benzenesulphonyl fluoride] in acute murine toxoplasmosis: R. Buitrago-Rey, et al.; J. Antimicrob. Chemother. 49, 871 (2002), Abstract; Full Text
4-(2-Aminoethyl)benzenesulfonyl fluoride attenuates tumor-necrosis-factor-alpha-induced blood-brain barrier opening: P. Megyeri, et al.; Eur. J. Pharmacol. 374, 207 (1999), Abstract;
Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds: V. Diatchuk, et al.; J. Biol. Chem. 272, 13292 (1997), Abstract; Full Text
Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF: M. Citron, et al.; Neuron 17, 171 (1996), Abstract;
Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor: Y. Nakabo & M.J. Pabst; J. Leukoc. Biol. 60, 328 (1996), Abstract; Full Text
Serine protease inhibitors block priming of monocytes for enhanced release of superoxide: P. Megyeri, et al.; Immunology 86, 629 (1995), Abstract; Full Text
Irreversible enzyme inhibitors. 180. Irreversible inhibitors of the C'la component of complement derived from m-(phenoxypropoxy)benzamidine and phenoxyacetamide: B.R. Baker & H.J. Cory; J. Med. Chem. 14, 119 (1971), Abstract;

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ALX-270-184-G005 5 g 75.00 USD
ALX-270-184-G025 25 g 208.00 USD
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