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Phenylmethylsulfonyl fluoride

Inhibitor of serine proteases and FAAH
ALX-270-184-G005 5 g 73.00 USD
ALX-270-184-G025 25 g 202.00 USD
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Irreversible inhibitor of serine proteases. Widely used fatty acid amid hydrolase (FAAH) inhibitor for pretreatment of brain membrane preparations when testing CB1 receptor activity. Spleen membranes used for CB2 studies do not require this pretreatment, as FAAH activity is absent in these cells. Inhibits also cysteine proteases like papain (reversible by DTT treatment, Prod. No. ALX-280-001), as well as internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor see AEBSF (Prod. No. ALX-270-022).

Product Details

Alternative Name:PMSF, Benzylsulfonyl fluoride
Purity:≥99% (HPLC)
Appearance:White to off-white needle crystals.
Solubility:Soluble in 100% ethanol, methanol or isopropanol; insoluble in water.
Shipping:Ambient Temperature
Long Term Storage:Ambient
Regulatory Status:RUO - Research Use Only
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Product Literature References

Electroacupuncture at GB34 modulates neurogenesis and BDNF-ERK signaling in a mouse model of Parkinson's disease: Y. Lee, et al.; J. Tradit. Complement. Med. 13, 263 (2023), Abstract;
A high spatial resolution osteogenic differentiation in human mesenchymal stem cells induced by femtosecond laser: S. Liu, et al.; J. Biophotononics 15, e202200144 (2022), Abstract;
Enhancing the Effect of Placental Extract on the Regeneration of Crush Injured Facial Nerve: G.M. Lim, et al.; Exp. Neurobiol. 31, 419 (2022), Abstract;
PUMILIO competes with AUF1 to control DICER1 RNA levels and miRNA processing: S. Rajasekaran, et al.; Nucleic Acids Res. 50, 7048 (2022), Abstract;
Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry: L.M.Q. Liao, et al.; J. Vis. Exp. (2021), Abstract;
Inhibition of Cyclic Adenosine Monophosphate-Specific Phosphodiesterase by Various Food Plant-Derived Phytotherapeutic Agents: T. Röhrig, et al.; Medicines (Basel) 4, 80 (2017), Abstract; Full Text
Identification of Novel Mutations in the LRR-Cap Domain of C21orf2 in Japanese Patients With Retinitis Pigmentosa and Cone-Rod Dystrophy: A. Suga, et al.; Invest. Ophthalmol. Vis. Sci. 57, 4255 (2016), Application(s): Western blot, isolated retina lysates, Abstract; Full Text
Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies: I. Albrecht, et al.; J. Clin. Invest. 125, 4612 (2015), Application(s): Skeletal muscle cell culture, Abstract; Full Text
Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist: D.G. Deutsch & S.A. Chin; Biochem. Pharmacol. 46, 791 (1993), Abstract;
Inactivation of the protease inhibitor phenylmethylsulfonyl fluoride in buffers: G.T. James; Anal. Biochem. 86, 574 (1978), Abstract;
Kinetic analysis of differences in brain acetylcholinesterase from fish or mammalian sources: D.E. Moss & D.E. Fahrney; Biochem. Pharmacol. 27, 2693 (1978), Abstract;

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