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ALK5 Inhibitor II

ALX-270-445-M001 1 mg 86.00 USD
ALX-270-445-M005 5 mg 347.00 USD
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Cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=23nM, 4nM and 18nM for binding, auto-phosphorylation and cellular assay in HepG2 cells of TGF-β RI kinase, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC50>16µM).

Product Details

Alternative Name:TGF-β RI Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
Purity:≥97% (HPLC)
Identity:Determined by NMR.
Appearance:White to off-white or yellow solid.
Solubility:5mg/ml soluble in DMSO or methanol.
Long Term Storage:-20°C
Use/Stability:Stable for 2 years after receipt when stored at -20°C. Stock solutions are stable for up to 6 months when stored at -20°C.
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

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Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells: L. Velazco-Cruz, et al.; Stem Cell Reports 12, 351 (2019), Application(s): Treatment of hESC culture, Abstract; Full Text
Glucose-Responsiveness of Pancreatic β-Like (GRP β-L) Cells Generated from Human Pluripotent Stem Cells: B. Rajaei, et al.; Curr. Protoc. Hum. Genet. 100, e71 (2019), Abstract;
Point mutations in the PDX1 transactivation domain impair human β-cell development and function: X. Wang, et al.; Mol. Metab. 24, 80 (2019), Abstract; Full Text
Generation and selection of pluripotent stem cells for robust differentiation to insulin-secreting cells capable of reversing diabetes in rodents: S.M. Southard, et al.; PLoS One 9, e0203126 (2018), Abstract; Full Text
Intrinsic Immunity Shapes Viral Resistance of Stem Cells: X. Wu, et al.; Cell 3, 423 (2018), Abstract; Full Text
Modeling signaling-dependent pluripotency with Boolean logic to predict cell fate transitions: A. Yachie-Kinoshita, et al.; Mol. Syst. Biol. 14, e7952 (2018), Abstract; Full Text
Cultured circulating tumor cells and their derived xenografts for personalized oncology: R. Wang, et al.; Asian J. Urol. 4, 240 (2016), Abstract; Full Text
Economic 3D-printing approach for transplantation of human stem cell-derived β-like cells: J. Song, et al.; Biofabrication 9, 015002 (2016), Abstract;
ERRγ Is required for the metabolic maturation of therapeutically functional glucose-responsive β cells: E. Yoshihara, et al.; Cell Metab. 23, 622 (2016), Abstract; Full Text
Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mic: A.J. Vegas, et al.; Nat. Med. 22, 306 (2016), Abstract; Full Text
Emdogain-regulated gene expression in palatal fibroblasts requires TGF-βRI kinase signaling: A. Stähli, et al.; PLoS One 9, e105672 (2014), Abstract; Full Text
Generation of functional human pancreatic β cells in vitro: F.W. Pagliuca, et al.; Cell 159, 428 (2014), Abstract; Full Text
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells: A. Rezania, et al.; Nat. Biotechnol. 32, 1121 (2014), Application(s): Treatment of human iPSC-derived pancreatic endocrine precursors, Abstract;
Inhibitors of Src and focal adhesion kinase promote endocrine specification: impact on the derivation of β-cells from human pluripotent stem cells: I. Afrikanova, et al.; J. Biol. Chem. 286, 36042 (2011), Abstract; Full Text
A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog: J.K. Ichida, et al.; Cell Stem Cell 5, 491 (2009), Abstract;
Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors: F. Gellibert, et al.; J. Med. Chem. 47, 4494 (2004), Abstract;