- Potent ATP-competitive inhibitor of the TGF-β type I receptor ALK5
- Useful for cellular reprogramming and the culture of human pluripotent stem cells
- Active in vitroand in vivo
ALK5 inhibitor II is a cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=23nM, 4nM and 18nM for binding, auto-phosphorylation, and cellular assay in HepG2 cells of TGF-β RI kinase, respectively). It minimally affects a panel of nine closely related kinases including p38 MAPKand GSK3 (IC50>16µM). It can be used for the induction of the pluripotency of stem cells by replacing the transcription factor SOX2 via the inhibition of TGF-β signaling and inducing the expression of the transcription factor Nanog.
Product Details
| Alternative Name: | TGF-β RI Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine |
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| Formula: | C17H13N5 |
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| MW: | 287.3 |
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| CAS: | 446859-33-2 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Identity determined by NMR. |
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| Appearance: | White to off-white or yellow solid. |
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| Solubility: | Soluble in DMSO (5 mg/ml) or methanol (5 mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for 2 years after receipt when stored at -20°C. Stock solutions are stable for up to 6 months when stored at -20°C. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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