Cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=23nM, 4nM and 18nM for binding, auto-phosphorylation and cellular assay in HepG2 cells of TGF-β RI kinase, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC50>16µM).
Product Details
| Alternative Name: | TGF-β RI Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine |
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| Formula: | C17H13N5 |
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| MW: | 287.3 |
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| CAS: | 446859-33-2 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | White to off-white or yellow solid. |
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| Solubility: | 5mg/ml soluble in DMSO or methanol. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for 2 years after receipt when stored at -20°C. Stock solutions are stable for up to 6 months when stored at -20°C. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Intrinsic Immunity Shapes Viral Resistance of Stem Cells: X. Wu, et al.; Cell
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Economic 3D-printing approach for transplantation of human stem cell-derived β-like cells: J. Song, et al.; Biofabrication
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Emdogain-regulated gene expression in palatal fibroblasts requires TGF-βRI kinase signaling: A. Stähli, et al.; PLoS One
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Generation of functional human pancreatic β cells in vitro: F.W. Pagliuca, et al.; Cell
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A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog: J.K. Ichida, et al.; Cell Stem Cell
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