Intermediate in the biosynthesis of 1α,25-dihydroxyvitamin D3. Major circulating metabolite of vitamin D3.
Product Details
| Alternative Name: | Calcifediol, 25-Hydroxycholecalciferol |
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| Formula: | C27H44O2 |
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| MW: | 400.6 |
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| CAS: | 19356-17-3 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white crystalline solid. |
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| Solubility: | Soluble in 100% ethanol. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light and oxygen. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells: D. Chauss, et al.; Nat. Immunol.
23, 62 (2022),
Abstract;
Impaired Vitamin D Signaling in T Cells From a Family With Hereditary Vitamin D Resistant Rickets: F.A.H. Al-Jaberi, et al.; Front. Immunol.
12, 684015 (2021),
Abstract;
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CD55 regulates bone mass in mice by modulating RANKL-mediated Rac signaling and osteoclast function: B. Shin, et al.; J. Bone Miner. Res.
35, 130 (2020),
Abstract;
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Heterogeneous GM-CSF signaling in macrophages is associated with control of Mycobacterium tuberculosis: B.D. Bryson, et al.; Nat. Commun.
10, 2329 (2019),
Abstract;
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Intrinsic activation of the vitamin D antimicrobial pathway by M. leprae infection is inhibited by type I IFN: K. Zavala, et al.; PLoS Negl. Trop. Dis.
12, e0006815 (2018),
Abstract;
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Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions: M. Mihajlovic, et al.; Int. J. Mol. Sci.
18, 2531 (2017),
Abstract;
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Vitamin D Counteracts Mycobacterium tuberculosis-Induced Cathelicidin Downregulation in Dendritic Cells and Allows Th1 Differentiation and IFNγ Secretion: A.K.O. Rode, et al.; Front. Immunol.
8, 656 (2017),
Abstract;
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Identification and characterization of a vitamin D3 decomposition product bactericidal against Helicobacter pylori: K. Hosoda, et al.; Sci. Rep.
5, 8860 (2015),
Abstract;
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Vitamin D promotes human extravillous trophoblast invasion in vitro: S.Y. Chan, et al.; Placenta
36, 403 (2015),
Application(s): Cell Culture,
Abstract;
Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells: M. Kongsbak, et al.; PLoS One
9, e96695 (2014),
Abstract;
Vitamin D-binding protein controls T cell responses to vitamin D: M. Kongsbak, et al.; BMC Immunol.
15, 35 (2014),
Abstract;
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25-hydroxyvitamin D3 suppresses hepatitis C virus production: T. Matsumura, et al.; Hepatology
56, 1231 (2012),
Application(s): Treatment of HCV-infected liver cells,
Abstract;
Effect of 25-hydroxyvitamin D3 and 1α,25 dihydroxyvitamin D3 on differentiation and apoptosis of human osteosarcoma cell lines: L. Thompson, et al.; J. Orthop. Res.
30, 831 (2012),
Application(s): Treatment of human osteosarcoma cell lines,
Abstract;
Vitamin D metabolites and analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cell line: D. Somjen, et al.; J. Steroid. Biochem. Mol. Biol.
123, 85 (2011),
Application(s): Treatment of human bone cells,
Abstract;
General Literature References
Enzyme immunoassay for plasma 25-hydroxyvitamin D3 employing immunoaffinity chromatography as a pretreatment method: N. Kobayashi, et al.; J.Steroid Biochem. Mol. Biol. 44, 93 (1993),
Evidence for human placental synthesis of 24,25-dihydroxyvitamin D3 and 23,25-dihydroxyvitamin D3: L.P Rubin, et al.; Pediatr. Res. 34, 98 (1993),
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