R-848 is a selective ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in human. Potent antitumor and antiviral compound. Stimulates antibody secretion, cytokine production, protection from apoptosis and CD80 upregulation.
Product Details
Alternative Name: | 4-Amino-2-(ethoxymethyl)-a,a-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol, S 28463, Resiquimod |
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Formula: | C17H22N4O2 |
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MW: | 314.4 |
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Source: | Synthetic |
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CAS: | 144875-48-9 |
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Purity: | ≥98% (HPLC) |
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Identity: | Identity determined by MS, 1H-NMR and 13C-NMR. |
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Endotoxin Content: | Endotoxin-free |
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Appearance: | White to off-white solid. |
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Solubility: | Soluble in DMSO, dichloromethane, 100% or 5% methanol; poorly soluble in acetonitrile or ethyl acetate. |
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Shipping: | Ambient |
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Long Term Storage: | -20°C |
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Regulatory Status: | RUO - Research Use Only |
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A novel polymorphism of the human CD40 receptor with enhanced function: A.L. Peters, et al.; Blood
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Treatment of intravaginal HSV-2 infection in mice: a comparison of CpG oligodeoxynucleotides and resiquimod (R-848): M.J. McCluskie, et al.; Antiviral Res.
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