Replaces Prod. #: BML-PI105
Irreversible inhibitor of cysteine proteinases like papain, calpain, cathepsin B, L and H. Acts by forming a thioether bond with the thiol of the active cysteine. Does not inhibit serine proteinases. Inhibits degradation of autophagic cargo in autophagolysosomes.
Product Details
| Alternative Name: | N-[N-(L-3-trans-Carboxyoxirane-2-carbonyl]-L-leucyl)-agmatine, L-trans-Epoxysuccinyl-leucylamide-(4-guanido)-butane |
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| Formula: | C15H27N5O5 . 0.5 H20 |
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| MW: | 357.4 |
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| Source: | Synthetic. |
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| CAS: | 66701-25-5 |
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| Purity: | ≥98% |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water/ethanol 1:1 mixture (15 mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Variable Processing and Cross-presentation of HIV by Dendritic Cells and Macrophages Shapes CTL Immunodominance and Immune Escape: J. Dinter, et al.; PLoS Pathog.
11, e1004725 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Efficient synthetic method for ethyl (+)-(2S,3S)-3-[(S)-3-methyl- 1-(3-methylbutylcarbamoyl)butylcarbamoyl]-2-oxiranecarb oxylate (EST), a new inhibitor of cysteine proteinases: M. Tamai, et al.; Chem. Pharm. Bull. (Tokyo)
35, 1098 (1987),
Abstract;
Isolation and Characterization of E-64, a New Thiol Protease Inhibitor: K. Hanada, et al.; Agric. Biol. Chem.
42, 523 (1978),
Full Text
Structure and Synthesis of E-64, a New Thiol Protease Inhibitor: K. Hanada, et al.; Agric. Biol. Chem.
42, 529 (1978),
Full Text
