Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 


Protease inhibitor
ALX-260-007-M005 5 mg 111.00 USD
ALX-260-007-M025 25 mg 400.00 USD
Do you need bulk/larger quantities?
Replaces Prod. #: BML-PI105

Irreversible inhibitor of cysteine proteinases like papain, calpain, cathepsin B, L and H. Acts by forming a thioether bond with the thiol of the active cysteine. Does not inhibit serine proteinases. Inhibits degradation of autophagic cargo in autophagolysosomes.

Product Details

Alternative Name:N-[N-(L-3-trans-Carboxyoxirane-2-carbonyl]-L-leucyl)-agmatine, L-trans-Epoxysuccinyl-leucylamide-(4-guanido)-butane
Formula:C15H27N5O5 . 0.5 H20
Appearance:White to off-white solid.
Solubility:Soluble in water/ethanol 1:1 mixture (15 mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
Please mouse over

Product Literature References

Variable Processing and Cross-presentation of HIV by Dendritic Cells and Macrophages Shapes CTL Immunodominance and Immune Escape: J. Dinter, et al.; PLoS Pathog. 11, e1004725 (2015), Application(s): Cell Culture, Abstract; Full Text
Efficient synthetic method for ethyl (+)-(2S,3S)-3-[(S)-3-methyl- 1-(3-methylbutylcarbamoyl)butylcarbamoyl]-2-oxiranecarb oxylate (EST), a new inhibitor of cysteine proteinases: M. Tamai, et al.; Chem. Pharm. Bull. (Tokyo) 35, 1098 (1987), Abstract;
Isolation and Characterization of E-64, a New Thiol Protease Inhibitor: K. Hanada, et al.; Agric. Biol. Chem. 42, 523 (1978), Full Text
Structure and Synthesis of E-64, a New Thiol Protease Inhibitor: K. Hanada, et al.; Agric. Biol. Chem. 42, 529 (1978), Full Text

Related Literature

Download as PDF

All new literature pieces