Replaces Prod. #: BML-PI120
Inhibitor of aspartate (acid) proteases, including pepsin, cathepsin D, renin, chymosin, bacterial aspartic proteinases and HIV proteases. Efficiently inhibits Fcγ receptor induction by IFN-γ. Blocks the endocytic pathway followed by an antibody when it enters the cell at the level of early endosomal compartments, resulting in inhibition of autoantigen presentation or viral transmission. Suppresses p-53-dependent apoptosis in lymphoid cells as well as TNFα-induced apoptosis in U937 cells. Inhibits degradation of autophagic cargo inside autophagolysosomes.
Product Details
| Alternative Name: | Iva-Val-Val-Sta-Ala-Sta, i-Valeryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA |
| |
| Sequence: | i-Valeryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA
(AHMHA = (3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid) |
| |
| Formula: | C34H63N5O9 |
| |
| MW: | 685.9 |
| |
| Source: | Synthetic. |
| |
| CAS: | 26305-03-3 |
| |
| MI: | 14: 7147 |
| |
| RTECS: | SC6155000 |
| |
| Purity: | ≥98% (HPLC) |
| |
| Appearance: | White to off-white solid. |
| |
| Solubility: | Soluble in DMSO (10mg/ml), methanol (1mg/ml) or acetic acid. |
| |
| Shipping: | Ambient |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Stable for at least 2 years after receipt when stored at -20°C. |
| |
| Handling: | Protect from light. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Product Literature References
Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination: C. Blázquez, et al.; Elife
9, 5681 (2021),
Abstract;
Full Text
Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry: L.M.Q. Liao, et al.; J. Vis. Exp. (2021),
Abstract;
Anti-cancer potential of persimmon (Diospyros kaki) leaves via the PDGFR-Rac-JNK pathway: H. Kim, et al.; Sci. Rep.
10, 18119 (2020),
Abstract;
Full Text
Induction of Lysosomal Membrane Permeabilization Is a Major Event of FTY720-Mediated Non-Apoptotic Cell Death in Human Glioma Cells: M.B. Reis, et al.; Nat. Commun.
11, 5433 (2020),
Abstract;
Full Text
Lysosomal dysfunction and autophagy blockade contribute to MDMA-induced neurotoxicity in SH-SY5Y neuroblastoma cells: I.H. Li, et al.; Chem. Res. Toxicol.
33, 903 (2020),
Abstract;
Expression and Purification of a Mammalian P2X7 Receptor from Sf9 Insect Cells: A. Karasawa, et al.; Bio Protoc.
7, e2544 (2017),
Abstract;
Full Text
Ferroquine, the next generation antimalarial drug, has antitumor activity: A. Kondratskyi, et al.; Sci. Rep.
7, 15896 (2017),
Abstract;
Full Text
Inhibition of Cyclic Adenosine Monophosphate-Specific Phosphodiesterase by Various Food Plant-Derived Phytotherapeutic Agents: T. Röhrig, et al.; Medicines (Basel)
4, 80 (2017),
Abstract;
Full Text
Initial autophagic protection switches to disruption of autophagic flux by lysosomal instability during cadmium stress accrual in renal NRK-52E cells: W.K. Lee, et al.; Arch. Toxicol.
91, 3225 (2017),
Abstract;
Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients: C. Valdez, et al.; Hum. Mol. Genet.
26, 4861 (2017),
Abstract;
Full Text
Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization: S. Hernandez-Tiedra, et al.; Autophagy
12, 2213 (2016),
Abstract;
Full Text
Neutrophil and Alveolar Macrophage-Mediated Innate Immune Control of Legionella pneumophila Lung Infection via TNF and ROS: P. Ziltener, et al.; PloS One.
12, e01005591 (2016),
Application(s): Cell culture,
Abstract;
Full Text
Autophagy limits proliferation and glycolytic metabolism in acute myeloid leukemia: A.S. Watson, et al.; Cell Death Discov.
1, 15008 (2015),
Application(s): Autophagy assay in human and mouse HSCs,
Abstract;
Full Text
Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies: I. Albrecht, et al.; J. Clin. Invest.
125, 4612 (2015),
Application(s): Skeletal muscle cell culture,
Abstract;
Full Text
Lysosomal Degradation of CD44 Mediates Ceramide Nanoliposome-induced Anoikis and Diminished Extravasation in Metastatic Carcinoma Cells: J. K. Haakenson, et al.; J. Biol. Chem.
290, 8632 (2015),
Application(s): Cell Culture ,
Abstract;
Full Text
Variable Processing and Cross-presentation of HIV by Dendritic Cells and Macrophages Shapes CTL Immunodominance and Immune Escape: J. Dinter, et al.; PLoS Pathog.
11, e1004725 (2015),
Application(s): Cell Culture,
Abstract;
Full Text
Marchantin M: a novel inhibitor of proteasome induces autophagic cell death in prostate cancer cells: H. Jiang, et al.; Cell Death Dis.
4, e761 (2013),
Application(s): Inhibitor of 20S proteasome for kinetics assay,
Abstract;
Full Text
Mast Cell Subsets and Their Functional Modulation by the Acanthocheilonema viteae Product ES-62: D.H. Ball, et al.; J. Parasitol. Res.
2013, 961268 (2013),
Abstract;
Full Text
Localization of pepstatin's inhibitory action during Fc-mediated antibody internalization: possible implications for antibody-mediated viral transmission: I. Athanassakis, et al.; Cell. Immunol.
199, 81 (2000),
Abstract;
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity: G.S. Wu, et al.; Oncogene
16, 2177 (1998),
Abstract;
Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alpha: L.P. Deiss, et al. ; EMBO J.
15, 3861 (1996),
Abstract;
Pepstatin, a new pepsin inhibitor produced by Actinomycetes: H. Umezawa, et al.; J. Antibiot.
23, 259 (1970),
Abstract;
