Replaces Prod. #: BML-PI120
Inhibitor of aspartate (acid) proteases, including pepsin, cathepsin D, renin, chymosin, bacterial aspartic proteinases and HIV proteases. Efficiently inhibits Fcγ receptor induction by IFN-γ. Blocks the endocytic pathway followed by an antibody when it enters the cell at the level of early endosomal compartments, resulting in inhibition of autoantigen presentation or viral transmission. Suppresses p-53-dependent apoptosis in lymphoid cells as well as TNFα-induced apoptosis in U937 cells. Inhibits degradation of autophagic cargo inside autophagolysosomes.
Product Details
Alternative Name: | Iva-Val-Val-Sta-Ala-Sta, i-Valeryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA |
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Sequence: | i-Valeryl-L-Val-L-Val-AHMHA-L-Ala-AHMHA (AHMHA = (3S,4S)-4-Amino-3-hydroxy-6-methyl-heptanoic acid) |
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Formula: | C34H63N5O9 |
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MW: | 685.9 |
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Source: | Synthetic. |
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CAS: | 26305-03-3 |
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MI: | 14: 7147 |
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RTECS: | SC6155000 |
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Purity: | ≥98% (HPLC) |
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Appearance: | White to off-white solid. |
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Solubility: | Soluble in DMSO (10mg/ml), methanol (1mg/ml) or acetic acid. |
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Shipping: | Ambient |
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Long Term Storage: | -20°C |
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Use/Stability: | Stable for at least 2 years after receipt when stored at -20°C. |
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Handling: | Protect from light. |
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Regulatory Status: | RUO - Research Use Only |
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