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SCREEN-WELL® Cardiotoxicity library

Essential standards for predictive toxicology screening
BML-2850-0100 1 Library 100 µl/well 2,434.00 USD
BML-2850-0500 1 Library 500 µl/well 7,298.00 USD
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The SCREEN-WELL® Cardiotoxicity Library is a focused collection of 130 compounds with defined and diverse cardiotoxicity, including ion channel blockage, mitochondrial toxicity, arrhythmia, fibrosis, and many more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. The compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates. The library is an essential tool for predictive toxicology screening and assay development.

Product Details

Contents:130 compounds with defined and diverse cardiotoxicity. A variety of structurally and mechanistically different compound classes, as well as nontoxic controls, are included.
Quantity:100 µl/well or 500 µl/well
Concentration:DMSO solutions (10mM).
Use/Stability:Stable for at least one year from the date of receipt when stored at -80°C.
Handling:Avoid freeze/thaw cycles.
Shipping:Dry Ice
Long Term Storage:-80°C
Technical Info/Product Notes:

Application Note (Cardiotoxicity Application):
Multi‐Parameter in vitro Assessment of Compound Effects on Cardiomyocyte Physiology Using Induced Pluripotent Stem Cells (iPSC)
Regulatory Status:RUO - Research Use Only

Product Literature References

Prediction of drug-induced liver injury and cardiotoxicity using chemical structure and in vitro assay data: L. Ye, et al.; Toxicol. Appl. Pharmacol. 454, 116250 (2022), Abstract;
Multiparameter Phenotypic Profiling in MCF-7 Cells for Assessing the Toxicity and Estrogenic Activity of Whole Environmental Water: W. Wang, et al.; Environ Sci. Technol. 52, 9277 (2018), Application(s): Phenotypic Profiling in MCF‑7 Cells, Abstract;
hiPSC-CM Monolayer Maturation State Determines Drug Responsiveness in High Throughput Pro-Arrhythmia Screen: A.M. da Rocha, et al.; Sci Rep. 7, 13834 (2017), Abstract; Full Text
Assessment of drug-induced arrhythmic risk using limit cycle and autocorrelation analysis of human iPSC-cardiomyocyte contractility: R.J. Kirby, et al.; Toxicol. Appl. Pharmacol. 305, 250 (2016), Application(s): Cardiomyocyte contractility patterns and autocorrelation to drug-induced beat irregularity with known hERG inhibitors, Abstract;
Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity: O. Sirenko, et al.; Toxicol. Appl. Pharmacol. 273, 500 (2013), Abstract;
Multiparameter in vitro assessment of compounds effects on cardiomyocyte physiology using iPSC cells: O. Sirenko, et al.; J. Biomol. Screen. 18, 39 (2013), Abstract;

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