27-Hydroxycholesterol (27-HC) is a metabolite resulting from the action of sterol 27-Hydroxylase on cholesterol. It is an endogenous selective estrogen receptor modulator and ligand for the liver X receptor (LXR). 27-Hydroxycholesterol plays a role in Alzheimer's disease, oxidative stress, metabolism, cell-signaling, and heart disease.
Product Details
| Alternative Name: | 5,25R-Cholesten-3β,26-diol, (25R)-26-Hydroxycholesterol |
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| Formula: | C27H46O2 |
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| MW: | 402.7 |
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| CAS: | 20380-11-4 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (up to 10 mg/ml with warming) or in ethanol (up to 10 mg/ml). Insoluble in water. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable, as supplied, for 2 years. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes: S. M. Kim, et al.; Toxicol. Appl. Pharmacol.
274, 462 (2014),
Abstract;
Increased 27-hydroxycholesterol plasma level in men with low high density lipoprotein-cholesterol may circumvent their reduced cell cholesterol efflux rate: V. S. Nunes, et al.; Clin. Chim. Acta.
433, 169 (2014),
Abstract;
Up-regulation of β-amyloidogenesis in neuron-like human cells by both 24- and 27-hydroxycholesterol: protective effect of N-acetyl-cysteine: P. Gamba, et al.; Aging Cell
13, 561 (2014),
Abstract;
27-hydroxycholesterol induces production of tumor necrosis factor-alpha from macrophages: S. M. Kim, et al.; Biochem. Biophys. Res. Commun.
430, 454 (2013),
Abstract;
27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology: E. R. Nelson, et al.; Science
342, 1094 (2013),
Abstract;
27-Hydroxycholesterol promotes cell-autonomous, ER-positive breast cancer growth: Q. Wu, et al.; Cell Rep.
5, 637 (2013),
Abstract;
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Relationships of coronary heart disease with 27-hydroxycholesterol, low-density lipoprotein cholesterol, and menopausal hormone therapy: J. E. Rossou, et al.; Circulation
126, 1577 (2012),
Abstract;
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Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation: M. Shafaati, et al.; J. Lipid Res.
52, 1004 (2011),
Abstract;
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Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism: R. Karuna, et al.; Atherosclerosis
214, 448 (2011),
Abstract;
Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain: M. Heverin, et al.; J. Lipid Res.
46, 1047 (2005),
Abstract;
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