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Akt Pathway Discovery

From Target Selection to Lead Profiling

Optimized solutions ensure higher quality hits resulting in fewer false leads

The Akt/PKB pathway is a popular target since it sits at the crossroads of both oncogenic and tumor suppressor signaling pathways. Enzo provides novel tools to help support cancer discovery from target selection, hit-to-lead discovery, and lead profiling.

 
SCREEN-WELL® Kinase Inhibitor Library

Benchmarks against 80 known kinase inhibitors with well-defined activity



Wortmannin, a PI 3-Kinase inhibitor
PKA, PKB, PKC Kinase Activity Assays

Minimize false positives or negatives seen with fluorescent compounds



Analysis of purified PKB activity
CELLESTIAL® Assays

High specifi city and low background fluorescent probes for live cell analysis



Multiplex assay that distinguishes between apoptosis and necrosis

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