Enzo Life Sciences offers more than 40 unique serine protease related products specifically related to cancer biomarker discovery, with emphasis on key family members identified as markers of early stage ovarian, breast, prostate and lung cancer (see table).
Serine proteases (or serine endopeptidases) are enzymes that breakdown proteins in extracellular compartments by cleavage of peptide bonds in the proteins. There are at least 14 family members found ubiquitously in both eukaryotes and prokaryotes. In humans, they are responsible for coordinating various physiological functions including digestion, immune response, blood coagulation and reproduction. Dysfunction often leads to human diseases and disorders, and mutations may lead to decreased or increased enzymatic activity. In cancer, serine proteases mediate a variety of events relevant to fundamental processes of tumor invasion and metastasis. In ovarian cancer, they are thought to promote tumor growth and dissemination, and their production can be detected early in tumor formation. The link between serine protease functions and cancer outcomes suggests that they may be a suitable target for therapeutic agents aimed at prevention of tumor progression and metastasis. As a tumor biomarker, serine proteases hold promise as a means of identifying certain cancers at an earlier stage to guide treatment and improve outcome.
SLPI (human), ELISA kit |
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| Rapid ELISA kit to quantify SLPI, a secretory leukocyte peptidase inhibitor and unique cancer biomarker. | ||||||
| ELISA, Colorimetric detection | Print as PDF | ||||||
| ADI-900-222-0001 | 96 wells | 788.00 USD |  |
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| Do you need bulk/larger quantities? | ||||||
Kallikrein-8 (human), (recombinant) (His-tag) |
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| Produced in insect cells. Human recombinant KLK8 (aa 24-260) is fused to a His-tag. Produced in a baculovirus expression system., ≥90% (SDS-PAGE), ELISA, WB | Print as PDF | ||||||
| ADI-908-300-0010 | 10 µg | Inquire for pricing | ||||
| Do you need bulk/larger quantities? | ||||||
Kallikrein-7 (human), (recombinant) (His-tag) |
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| Produced in insect cells. Human recombinant KLK7 (aa 21-253) is fused to a His-tag. Produced in a baculovirus expression system. , ≥90% (SDS-PAGE), ELISA, WB | Print as PDF | ||||||
| ADI-908-302-0010 | 10 µg | Inquire for pricing | ||||
| Do you need bulk/larger quantities? | ||||||
SLPI (human), (recombinant) (His-tag) |
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| Produced in insect cells. Human recombiinant SLPI (aa 25-132) is fused to a His-tag. Produced in a baculovirus expression system., ≥90% (SDS-PAGE), WB, in vitro Assay | Print as PDF | ||||||
| ADI-908-304-0010 | 10 µg | Inquire for pricing | ||||
| Do you need bulk/larger quantities? | ||||||
Kallikrein-6 (human), (recombinant) (His-tag) |
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| Produced in insect cells. Human recombinant KLK6 (aa 17-244) is fused to a His-tag. Produced in a baculovirus expression system., ≥90% (SDS-PAGE), ELISA, WB | Print as PDF | ||||||
| ADI-908-305-0010 | 10 µg | Inquire for pricing | ||||
| Do you need bulk/larger quantities? | ||||||
