Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 


ErbB-1, -2 and -4 tyrosine kinase inhibitor
ENZ-CHM158-0005 5 mg 124.00 USD
Do you need bulk/larger quantities?
Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signaling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumor growth was inhibited by Afatinib very effectively with low nanomolar IC50 values ranging from approximately 6nM to below 500 nM.

Product Details

Alternative Name:Tovok, BIBW-2992
Purity:≥95% (HPLC)
Identity:Determined by EM-MS, NMR
Appearance:Yellow powder.
Solubility:Soluble in DMSO (97 mg/ml) or ethanol (15 mg/ml).
Shipping:Ambient Temperature
Short Term Storage:+4°C
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
ENZ-CHM158 structure
Please mouse over
ENZ-CHM158 structure