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Spin Traps & Spin Probes

High Purity & Stable Spin Traps

Spin trapping is a common analytical method for the detection of free radicals. The spin trap molecule (e.g., PBN, DMPO, TEMPO) reacts with a typically transient free radical species, thus “trapping” the free radical in the form of a more stable spin adduct. Adducts can then be detected using electron paramagnetic resonance (EPR) spectroscopy.

Enzo offers a variety of spin traps and probes for the detection of general or specific free radical species. Our compounds are of the highest purity, ensuring the most consistent results.

  • Highest purity spin traps for in vitro and in vivo applications
  • No additional purification is required
  • All products are quality tested by ESR spectroscopy
 

DEPMPO 

Spin trapping reagent
157230-67-6, ≥99% (TLC) | Print as PDF
 
ALX-430-093-M050 50 mg 180.00 USD
 
ALX-430-093-M500 500 mg 1,403.00 USD
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BMPO (high purity) 

Spin trapping reagent
≥99% (HPLC) | Print as PDF
 
ALX-430-141-M010 10 mg 140.00 USD
 
ALX-430-141-M050 50 mg 508.00 USD
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DIPPMPO 

Spin trapping reagent
≥98% (TLC, 1H- and 13C-NMR) | Print as PDF
 
ALX-430-119-M050 50 mg 199.00 USD
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DMPO 

Spin trapping reagent
3317-61-1, ≥98% (ELSD) | Print as PDF
 
ALX-430-090-M500 500 mg 152.00 USD
 
ALX-430-090-G001 1 g 247.00 USD
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EMPO 

Spin trapping reagent
≥95% (HPLC) | Print as PDF
 
ALX-430-098-M050 50 mg Inquire for pricing
 
ALX-430-098-M010 10 mg 82.00 USD
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Cyclic Hydroxylamine Spin Probes

Spin trapping is widely used for unambiguous detection of free radicals, such as superoxide radical. Unfortunately, EPR detection of the O2 •- radicals in biological systems is limited by slow kinetics of O2 •- spin trapping (~55 M-1s-1) and biodegradation of the radical adducts (reduction to EPR silent hydroxylamines and oxidation to secondary nitrones) [1]. It has been previously shown that PP-H is an effective scavenger of the O2 •- [2], rapidly reacts with O2 •- to form stable nitroxides with a much longer half-life than O2 •- radical adducts. This is a distinct advantage of cyclic hydroxylamines over nitrone spin traps, which form relatively stable O2 •- adducts in cell-free systems [3], but these adducts rapidly degrade in biological samples [4]. Cyclic hydroxylamines react with O2 •- 100 times faster (~104 M-1s-1) than spin traps, which allow cyclic hydroxylamines to compete with cellular antioxidants and react with intracellular O2 •- . The lack of specificity of cyclic hydroxylamines can be overcome by use of superoxide dismutases or inhibitors of O2 •- production by NADPH oxidase, uncoupled eNOS (NOS III), xanthine oxidase, apocynin, L-NAME, and oxypurinol [5-7]. Cationic, anionic and neutral spin probes with various lipophilicity and cell permeability allow site-specific O2 •- detection with higher sensitivity than nitrone spin traps.

  1. M. Sentjurc & R. P. Mason; Free Radic. Biol. Med. 13, 151 (1992)
  2. S. I. Dikalov, et al.; Arch. Biochem. Biophys. 402, 218 (2002)
  3. H. Zhao, et al.; PNAS 102, 5727 (2005)
  4. K. Zwicker, et al.; Arzneimittelforschung 48, 629 (1998)
  5. N. Kuzkaya, et al.; Biochem. Pharmacol. 70, 343 (2005)
  6. K. E. Wyche, et al.; Hypertension 43, 1246 (2004)
  7. J. S. McNally, et al.; Arterioscler. Thromb. Vasc. Biol. 25, 1623 (2005)

Latest Literature

 

CAT1H . hydrochloride 

Spin probe
Print as PDF
 
ALX-430-131-M050 50 mg 246.00 USD
 
ALX-430-131-M250 250 mg 569.00 USD
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CMH . hydrochloride 

Spin probe reagent
≥99% (EPR) | Print as PDF
 
ALX-430-117-M010 10 mg 82.00 USD
 
ALX-430-117-M050 50 mg 246.00 USD
 
ALX-430-117-M250 250 mg 569.00 USD
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CPH . hydrochloride 

Spin probe reagent
92416-28-9 (non-salt), ≥99% (EPR) | Print as PDF
 
ALX-430-078-M010 10 mg 75.00 USD
 
ALX-430-078-M050 50 mg 246.00 USD
 
ALX-430-078-M250 250 mg 524.00 USD
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PPH . hydrochloride 

Spin trapping reagent
≥99% (EPR) | Print as PDF
 
ALX-430-080-M010 10 mg 104.00 USD
 
ALX-430-080-M050 50 mg 398.00 USD
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TMH . hydrochloride 

Spin probe
Print as PDF
 
ALX-430-132-M050 50 mg 228.00 USD
 
ALX-430-132-M250 250 mg 510.00 USD
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TMTH . hydrochloride 

Spin probe
≥99% (EPR) | Print as PDF
 
ALX-430-133-M050 50 mg 150.00 USD
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Nitric Oxide Spintrapping Reagents

Carboxy-PTIO 

Nitric oxide (NO) scavenger
148819-94-7, ≥99% (HPLC) | Print as PDF
 
ALX-430-001-M010 10 mg 56.00 USD
 
ALX-430-001-M050 50 mg 179.00 USD
 
ALX-430-001-M250 250 mg 680.00 USD
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Diethyldithiocarbamic acid . sodium salt . trihydrate (high purity) 

NO spin trapping reagent
20624-25-3, ≥99% (Titration) | Print as PDF
 
ALX-400-003-G025 25 g 56.00 USD
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MGD . sodium salt . monohydrate 

Spin trapping reagent
91840-27-6, ≥98% (HPLC) | Print as PDF
 
ALX-400-014-M050 50 mg 64.00 USD
 
ALX-400-014-M250 250 mg 169.00 USD
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Antioxidant Spin Probe – A Key Standard Compound

TEMPOL 

SOD mimetic
2226-96-2, ≥98% (HPLC) | Print as PDF
 
ALX-430-081-G001 1 g 49.00 USD
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Other Spin Traps & Spin Probes

DMPIO 

Spin trapping reagent
123557-86-8, ≥98% (GLC) | Print as PDF
 
ALX-430-088-M010 10 mg 31.00 USD
 
ALX-430-088-M050 50 mg 81.00 USD
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MCPIO 

Spin trapping reagent
≥98% (HPLC) | Print as PDF
 
ALX-430-083-M010 10 mg 10.00 USD
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POBN (high purity) 

Spin trapping reagent
66893-81-0, ≥99% (HPLC) | Print as PDF
 
ALX-430-091-M500 500 mg 168.00 USD
 
ALX-430-091-G001 1 g 261.00 USD
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PTIO 

Nitric oxide (NO) scavenger
18390-00-6, ≥98% (Nonaqueous Titration) | Print as PDF
 
ALX-430-007-M025 25 mg 37.00 USD
 
ALX-430-007-M100 100 mg 110.00 USD
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TEMPONE 

Spin trapping reagent
2896-70-0, ≥98% (Assay) | Print as PDF
 
ALX-430-079-M250 250 mg 10.00 USD
 
ALX-430-079-G001 1 g 36.00 USD
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TEMPONE-H . hydrochloride 

Spin trapping reagent
3637-11-4, ≥99% (GLC) | Print as PDF
 
ALX-430-071-M010 10 mg 75.00 USD
 
ALX-430-071-M050 50 mg 228.00 USD
 
ALX-430-071-M250 250 mg 571.00 USD
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TMIO 

Spin trapping reagent
136440-22-7, ≥98% (GLC) | Print as PDF
 
ALX-430-073-M250 250 mg 254.00 USD
 
ALX-430-073-G001 1 g 781.00 USD
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PBN 

Spin trapping reagent
3376-24-7, ≥98% (HPLC) | Print as PDF
 
ALX-430-082-G001 1 g 49.00 USD
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HQNO

HQNO 

NADH inhibitor
341-88-8, Synthetic., ≥99% (HPLC) | Print as PDF
 
ALX-430-130-M010 10 mg 116.00 USD
 
ALX-430-130-M050 50 mg 456.00 USD
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Efficient Cysteine-specific Spin Labeling Compound

MTSSL 

Thiol-specific spin label
81213-52-7, ≥98% (HPLC) | Print as PDF
 
ALX-430-134-M010 10 mg 77.00 USD
 
ALX-430-134-M050 50 mg 304.00 USD
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Fluorinated Spin Probe

pH-sensitive Spin Probes

Biradical Spin Label For Monitoring of Intracellular Redox States of Thiols

RSSR 

Supersensitive spin label
123557-49-3, ≥97% (HPLC, GLC) | Print as PDF
 
ALX-430-102-M025 25 mg 205.00 USD
 
ALX-430-102-M050 50 mg 365.00 USD
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