RSSR

Supersensitive spin label



ALX-430-102-M025	25 mg	Inquire for pricing

ALX-430-102-M050	50 mg	455.00 USD
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Cell permeable supersensitive spin label (detection limit varies from 10nM to 100nM) for quick detection of reduced thiols using ESR. Allows following the reactions of sulfhydryl groups with RSSR to form thiol spin label adducts, for the monitoring of intracellular redox states of glutathione and other thiols.

Product Details

Alternative Name:	bis-(2,2,5,5-Tetramethyl-3-imidazoline-1-oxyl-4-yl)disulfide, biradical

Formula:	C₁₄H₂₄N₄O₂S₂

MW:	344.5

CAS:	123557-49-3

Purity:	≥97% (HPLC, GLC)

Appearance:	Off-white to yellow crystalline powder.

Solubility:	Soluble in DMSO, water, 100% ethanol or methanol; DMSO is recommended for stock solution.

Shipping:	Dry Ice

Long Term Storage:	-20°C

Handling:	Protect from light.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Alterations in the Plasma and Red Blood Cell Properties in Patients with Varicose Vein: A Pilot Study: L. Gwozdzinski, et al.; Cardiol. Res. Pract. 2021, 5569961 (2021), Abstract;

In vitro and in vivo measurement of pH and thiols by EPR-based techniques: V.V. Khramtsov, et al.; Antioxid. Redox Signal. 6, 667 (2004), Abstract;

Unique in vivo applications of spin traps: L.J. Berliner, et al.; Free Radic. Biol. Med. 30, 489 (2001), Abstract;

Use of imidazoline nitroxides in studies of chemical reactions. ESR measurements of the concentration and reactivity of protons, thiols and nitric oxide.: V.V. Khramtsov & L. B. Volodarsky; Spin labeling. The next Millennium. 145, 109 (1998),

Quantitative determination and reversible modification of thiols using imidazolidine biradical disulfide label: V.V. Khramtsov, et al.; J. Biochem. Biophys. Methods 35, 115 (1997), Abstract;

Quantitative determination of thiol groups in low and high molecular weight compounds by electron paramagnetic resonance: L.M. Weiner; Meth. Enzymol. 251, 87 (1995), Abstract;

Quantitative determination of SH groups in low- and high-molecular-weight compounds by an electron spin resonance method: V.V. Khramtsov, et al.; Anal. Biochem. 182, 58 (1989), Abstract;