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Nitric oxide (NO) scavenger
ALX-430-001-M010 10 mg 67.00 USD
ALX-430-001-M050 50 mg 224.00 USD
ALX-430-001-M250 250 mg 859.00 USD
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Replaces Prod. #: BML-CN262

  • Highly pure NO scavenger
Carboxy-PTIO is a water-soluble and stable nitric oxide radical scavenger that shows in chemical and biological systems antagonistic action against the free nitric oxide radical (NO·) in a stoichiometric manner. The inhibitory effects are almost two-fold stronger than those of NMMA (Prod. No. ALX-106-001) and NOARG (Prod. No. ALX-105-001). Carboxy-PTIO can be used for an improved detection of nitric oxide in activated macrophage cultures in combination with the Griess reagent (Prod. No. ALX-400-004). Carboxy-PTIO also protects against endotoxin shock.

Product Details

Alternative Name:2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide . potassium salt
Formula:C14H16N2O4 . K
Purity:≥99% (HPLC)
Identity:Identity determined by MS and NMR.
Appearance:Blue solid.
Solubility:Soluble in DMF, DMSO, 100% ethanol, or 100% methanol. Highly soluble in water or aqueous buffers (e.g. PBS, pH 7.2).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli: A. Babosan, et al.; Elife 11, e69511 (2022), Abstract;
Protective effects of topical application of nitrite on testicular ischemia-reperfusion injury in rats: J.W. Lee, et al.; Oxid. Med. Cell. Longev. 2021, 5514537 (2021), Abstract; Full Text
Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION 2: D.J. Gibbs, et al.; Nat. Commun. 9, 5438 (2018), Abstract; Full Text
Sodium nitrite-derived nitric oxide protects rat testes against ischemia/reperfusion injury: J.W. Lee, et al.; Asian J. Androl. 21, 92 (2018), Abstract; Full Text
POLYAMINE OXIDASE2 of Arabidopsis contributes to ABA mediated plant developmental processes: R. Wimalasekera, et al. ; Plant Physiol. Biochem. 96, 231 (2015), Application(s): Fluorimetry, Abstract;
Limits in the use of cPTIO as nitric oxide scavenger and EPR probe in plant cells and seedlings: S. D'Alessandro, et al.; Front. Plant. Sci. 4, 340 (2013), Abstract; Full Text
COPPER AMINE OXIDASE1 (CuAO1) of Arabidopsis thaliana contributes to abscisic acid- and polyamine-induced nitric oxide biosynthesis and abscisic acid signal transduction: R. Wimalasekera, et al.; Mol. Plant 4, 663 (2011), Abstract;
Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases: M. Lee, et al.; FASEB J. 24, 2533 (2010), Abstract; Full Text
Nitric oxide binds to the proximal heme coordination site of the ferrocytochrome c/cardiolipin complex: formation mechanism and dynamics: G. Silkstone, et al.; J. Biol. Chem. 285, 19785 (2010), Abstract; Full Text
Enhancement of nitric oxide release from nitrosyl hemoglobin and nitrosyl myoglobin by red/near infrared radiation: potential role in cardioprotection: N.L. Lohr, et al.; J. Mol. Cell. Cardiol. 47, 256 (2009), Abstract; Full Text
Mitochondrial nitroalkene formation and mild uncoupling in ischaemic preconditioning: implications for cardioprotection: S.M. Nadtochiy, et al.; Cardiovasc. Res. 82, 333 (2009), Abstract; Full Text
Nitric oxide activation of guanylyl cyclase in cells revisited: B. Roy & J. Garthwaite; PNAS 103, 12185 (2006), Abstract;
Improved detection of nitric oxide radical (NO.) production in an activated macrophage culture with a radical scavenger, carboxy PTIO and Griess reagent: F. Amano & T. Noda; FEBS Lett. 368, 425 (1995), Abstract;
Therapeutic effects of imidazolineoxyl N-oxide against endotoxin shock through its direct nitric oxide-scavenging activity: M. Yoshida, et al.; BBRC 202, 923 (1994), Abstract;
Antagonistic action of imidazolineoxyl N-oxides against endothelium- derived relaxing factor/.NO through a radical reaction: T. Akaike, et al.; Biochemistry 32, 827 (1993), Abstract;
Pronounced enhancement of .NO-dependent antimicrobial action by an .NO- oxidizing agent, imidazolineoxyl N-oxide: K. Yoshida, et al.; Infect. Immun. 61, 3552 (1993), Abstract;

General Literature References

Reaction between imidazolineoxil N-oxide (carboxy-PTIO) and nitric oxide released from cultured endothelial cells: quantitative measurement of nitric oxide by ESR spectrometry: T. Az-ma, et al.; Life Sci. 54, PL185 (1994), Abstract;

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