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United States 

BMPO (high purity)

Spin trapping reagent
ALX-430-141-M010 10 mg 176.00 USD
ALX-430-141-M050 50 mg 641.00 USD
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  • Highly pure spin trapping reagent
  • Contains very low paramagnetic impurities and does not require further purification
  • Comes as a crystalline solid for a longer shelf-life
BMPO is a cyclic nitrone spin trap for the specific in vivo or in vitro detection of short-lived hydroxyl, superoxide, and thiyl radicals. BMPO forms distinguishable adducts that can be measured by EPR spectroscopy. Unlike with DMPO (Prod. No. ALX-430-090), the superoxide adduct does not decay into a hydroxyl adduct and has a much longer half-life in cells (t1/2=23min).

Product Details

Alternative Name:5-tert-Butoxycarbonyl-5-methyl-1-pyrroline-N-oxide
Purity:≥99% (HPLC)
Identity:Identity determined by MS and NMR.
Appearance:White to pinkish crystalline solid.
Solubility:Soluble in DMSO (25mg/ml), 100% ethanol, 100% methanol, and water.
Shipping:Blue Ice
Long Term Storage:-20°C
Handling:Protect from moisture.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Dynamic Wood Smoke Aerosol Toxicity during Oxidative Atmospheric Aging: S. Wang, et al.; Environ. Sci. Technol. 3, 1246 (2023), Abstract;
Effects of acidity on reactive oxygen species formation from secondary organic aerosols: J. Wei, et al.; ACS Environ. Au. 2, 336 (2022), Abstract;
Hydrothermal synthesis of PVP-passivated clove bud-derived carbon dots for antioxidant, catalysis, and cellular imaging applications: A.K. Pandey, et al.; Colloids Surf. B Biointerfaces 220, 112926 (2022), Abstract;
Activation of peroxymonosulfate by bicarbonate and acceleration of the reaction by freezing: Y.Y. Ah, et al.; Sci. Total Environ. 785, 147369 (2021), Abstract;
Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts: K. Nowotny, et al.; Free Radic. Biol. Med. 120, 102 (2018), Abstract;
Reactive Oxygen Species Formed by Secondary Organic Aerosols in Water and Surrogate Lung Fluid: H. Tong, et al.; Environ. Sci. Technol. 52, 11651 (2018), Abstract;
Reactive oxygen species formed in aqueous mixtures of secondary organicaerosols and mineral dust influencing cloud chemistry and public health in the Anthropocene: H. Tong, et al.; Faraday Discuss. 200, 251 (2017), Application(s): ROS detection in aqueous mixtures of SOA by applying electron paramagnetic resonance (EPR) spectrometry, Abstract; Full Text
Oxidation of the Flavonolignan Silybin. In situ EPR Evidence of the Spin-Trapped Silybin Radical: R. Sokolova, et al.; Electrochim. Acta 205, 118 (2016), Application(s): in situ EPR spectroelectrochemistry,
Mechanism of the hydroxyl radical oxidation of methacryloyl peroxynitrate (MPAN) and its pathway toward secondary organic aerosol formation in the atmosphere: T.B. Nguyen, et al.; Phys. Chem. Chem. Phys. 17, 17914 (2015), Application(s): Trapping agent of OH radicals, Abstract; Full Text
S-allyl cysteine alleviates nonsteroidal anti-inflammatory drug-induced gastric mucosal damages by increasing cyclooxygenase-2 inhibition, heme oxygenase-1 induction, and histone deacetylation inhibition: J.M. Park, et al.; J. Gastroenterol. Hepatol. 29 Suppl. 4, 80 (2014), Application(s): Electron spin resonance (ESR) spectroscopy, Abstract;
Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence: H. Zhao, et al.; PNAS 102, 5727 (2005), Abstract;
Evaluation of spin trapping agents and trapping conditions for detection of cell-generated reactive oxygen species: H. Shi, et al.; Arch. Biochem. Biophys. 437, 59 (2005), Abstract;
Spin traps: in vitro toxicity and stability of radical adducts: N. Khan, et al.; Free Radic. Biol. Med. 34, 1473 (2003), Abstract;
Synthesis and biochemical applications of a solid cyclic nitrone spin trap: a relatively superior trap for detecting superoxide anions and glutathiyl radicals: H. Zhao, et al.; Free Radic. Biol. Med. 31, 599 (2001), Abstract;

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