Cell permeable hydrophilic spin trap for both in vivo and in vitro studies. Water soluble analog of PBN (Prod. No. ALX-430-082). Low paramagnetic impurities. No further purification required.
Product Details
| Alternative Name: | α-(4-Pyridyl 1-oxide)-N-tert-butylnitrone |
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| Formula: | C10H14N2O2 |
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| MW: | 194.2 |
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| CAS: | 66893-81-0 |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | White to off-white or colorless crystalline solid. |
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| Solubility: | Soluble in DMSO, water, methanol or 100% ethanol. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Singlet oxygen production by photosystem II is caused by misses of the oxygen evolving complex: H. Mattila, et al.; New Phytol.
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Abstract;
Direct evidence of iNOS-mediated in vivo free radical production and protein oxidation in acetone-induced ketosis: K. Stadler, et al.; Am. J. Physiol. Endocrinol. Metab.
295, E456 (2008),
Abstract;
Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes: K. Stadler, et al.; Free Radic. Biol. Med.
45, 866 (2008),
Abstract;
Identification of free radical formation and F2-isoprostanes in vivo by acute Cr(VI) poisoning: M.B. Kadiiska, et al.; Chem. Res. Toxicol.
11, 1516 (1998),
Abstract;
The spin trap alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone stimulates peroxidase-mediated oxidation of deferoxamine. Implications for pharmacological use of spin-trapping agents: M.L. McCormick, et al.; J. Biol. Chem.
270, 29265 (1995),
Abstract;
Full Text
Polyunsaturated fatty acids increase lipid radical formation induced by oxidant stress in endothelial cells: L.S. Alexander-North, et al.; J. Lipid Res.
35, 1773 (1994),
Abstract;
In vitro and in vivo evidence for the formation of methyl radical from procarbazine: a spin-trapping study: L. Goria-Gatti, et al.; Carcinogenesis
13, 799 (1992),
Abstract;
Two decades of spin trapping: E.G. Janzen & D.L. Hare; Adv. Radic. Chem. 1, 253 (1990),
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