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United States 

MGD . sodium salt . monohydrate

Spin trapping reagent
ALX-400-014-M050 50 mg 77.00 USD
ALX-400-014-M250 250 mg 245.00 USD
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Together with FeSO4 MGD is a useful component for the formation of the MGD2-Fe2+complex, which is an excellent nitric oxide (NO) spin-trapping reagent. The MGD2-Fe2+complex is quite unstable, especially in the presence of dissolved oxygen. Thus, the complex should be used immediately after being made. An excess (usually 5-fold excess), of MGD to Fe2+ is used for making the complex with FeSO4 to give a more stable complex solution. Acidic conditions should be avoided because dithiocarbamate tends to decompose forming toxic carbon disulfide. It was reported that MGD and Fe(MGD)2 do not exhibit toxicity up to 8mmol/kg and 0.3mmol/kg, respectively.

Product Details

Alternative Name:N-(Dithiocarbamoyl)-N-methyl-D-glucamine . Na . H2O, N-Methyl-D-glucamine dithiocarbamate
Formula:C8H16NO5S2Na . H2O
MW:293.3 . 18.0
Purity:≥98% (HPLC)
Appearance:White to off-white solid.
Solubility:Soluble in water.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Handling:Protect from light.
Regulatory Status:RUO - Research Use Only
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Product Literature References

IL-1β reciprocally regulates chemokine and insulin secretion in pancreatic β-cells via NF-κB: S.J. Burke, et al.; Am. J. Physiol. Endocrinol. Metab. 309, E715 (2021), Abstract;
Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation: S.J. Burke, et al.; Mol. Metab. 14, 95 (2018), Application(s): Electron paramagnetic resonance spectroscopy (EPR) with cell culture media, Abstract; Full Text
Evaluation of lipid-based carrier systems and inclusion complexes of diethyldithiocarbamate-iron to trap nitric oxide in biological systems: N. Charlier, et al.; Magn. Reson. Med. 55, 215 (2006), Abstract;
Redox cycling of iron complexes of N-(dithiocarboxy)sarcosine and N-methyl-D-glucamine dithiocarbamate: C. Lu & W.H. Koppenol; Free Radic. Biol. Med. 39, 1581 (2005), Abstract;
EPR spectroscopy of common nitric oxide - spin trap complexes: S. Nedeianu & T. Pali; Cell. Mol. Biol. Lett. 7, 142 (2002), Abstract;
Detailed methods for the quantification of nitric oxide in aqueous solutions using either an oxygen monitor or EPR: S. Venkataraman, et al.; Free Radic. Biol. Med. 29, 580 (2000), Abstract;
Electron-paramagnetic resonance spectroscopy using N-methyl-D-glucamine dithiocarbamate iron cannot discriminate between nitric oxide and nitroxyl: implications for the detection of reaction products for nitric oxide synthase: A.M. Komarov, et al.; Free Radic. Biol. Med. 28, 793 (2000), Abstract;
Redox properties of iron-dithiocarbamates and their nitrosyl derivatives: implications for their use as traps of nitric oxide in biological systems: A.F. Vanin, et al.; Biochim. Biophys. Acta 1474, 365 (2000), Abstract;
Complexes of Fe2+ with diethyldithiocarbamate or N-methyl-D-glucamine dithiocarbamate as traps of nitric oxide in animal tissues: comparative investigations: V.D. Mikoyan, et al.; Biochim. Biophys. Acta 1336, 225 (1997), Abstract;
Continuous and quantitative monitoring of rate of cellular nitric oxide generation: Y. Kotake; Methods Enzymol. 268, 222 (1996), Abstract;
Continuous monitoring of cellular nitric oxide generation by spin trapping with an iron-dithiocarbamate complex: Y. Kotake, et al.; Biochim. Biophys. Acta 1289, 362 (1996), Abstract;
Spin trapping isotopically-labelled nitric oxide produced from [15N]L- arginine and [17O]dioxygen by activated macrophages using a water soluble Fe(++)-dithiocarbamate spin trap: Y. Kotake, et al.; Free Rad. Res. 23, 287 (1995), Abstract;
Spin trapping of nitric oxide produced in vivo in septic-shock mice: C.-S. Lei & A.M. Komarov; FEBS Lett. 345, 120 (1994), Abstract;
In vivo spin trapping of nitric oxide in mice: A. Komarov, et al.; BBRC 195, 1191 (1993), Abstract;
Sodium N-methyl-D-glucamine dithiocarbamate and cadmium intoxication: L.A. Shinobu, et al.; Acta Pharmacol. Toxicol. 54, 189 (1984), Abstract;

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