Beside DEPMPO (Prod. No. ALX-430-093), most efficient spin trap for the in vitro and in vivo detection of O-, N-, S-, and C-centered free radicals. Has a longer life-time than DMPO (Prod. No. ALX-430-090).
Product Details
| Alternative Name: | 2-Ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide |
| |
| Formula: | C8H13NO3 |
| |
| MW: | 171.2 |
| |
| Purity: | ≥95% (HPLC) |
| |
| Identity: | Determined by NMR. |
| |
| Appearance: | Colorless to light yellow oil. |
| |
| Solubility: | Soluble in water, DMSO, ethanol or dichloromethane. |
| |
| Shipping: | Blue Ice |
| |
| Short Term Storage: | -20°C |
| |
| Long Term Storage: | -80°C |
| |
| Use/Stability: | Store solutions at -20°C. |
| |
| Handling: | Protect from light. Hygroscopic. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Spectrum of the (O2-) – EMPO adduct.
Please mouse over
Product Literature References
EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines: S.I. Dikalov, et al.; Free Rad. Res.
45, 417 (2011),
Abstract;
Anti-inflammatory activity of Chios mastic gum is associated with inhibition of TNF-alpha induced oxidative stress: A. Triantafyllou, et al.; Nutrition
10, 64 (201),
Abstract;
Measurement of reactive oxygen species in cardiovascular studies: S. Dikalov, et al.; Hypertension
49, 717 (2007),
Abstract;
Mitochondrial redox cycling of mitoquinone leads to superoxide production and cellular apoptosis: A.K. Doughan & S.I Dikalov; Antioxid. Redox Signal.
9, 1825 (2007),
Abstract;
Indoxyl sulfate induces complex redox alterations in mesangial cells: A.K. Gelasco & J.R. Raymond; Am. J. Physiol. Renal Physiol.
290, F1551 (2006),
Abstract;
Spin trapping of C- and O-centered radicals with methyl-, ethyl-, pentyl-, and phenyl-substituted EMPO derivatives: K. Stolze, et al.; Bioorg. Med. Chem.
14, 3368 (2006),
Abstract;
The line asymmetry of electron spin resonance spectra as a tool to determine the cis:trans ratio for spin-trapping adducts of chiral pyrrolines N-oxides: the mechanism of formation of hydroxyl radical adducts of EMPO, DEPMPO, and DIPPMPO: M. Culcasi, et al.; Free Radic. Biol. Med.
40, 1524 (2006),
Abstract;
Cytotoxicity of novel derivatives of the spin trap EMPO: N. Rohr-Udilova, et al.; Bioorg. Med. Chem. Lett.
16, 541 (2005),
Abstract;
Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase: N. Kuzkaya, et al.; Biochem. Pharmacol.
70, 343 (2005),
Abstract;
Spin adduct formation from lipophilic EMPO-derived spin traps with various oxygen- and carbon-centered radicals: K. Stolze, et al.; Biochem. Pharmacol.
69, 297 (2005),
Abstract;
Spin trapping of superoxide by diester-nitrones: A. Allouch, et al.; Org. Biomol. Chem.
3, 2458 (2005),
Abstract;
Full Text
A new kinetic approach to the evaluation of rate constants for the spin trapping of superoxide/hydroperoxyl radical by nitrones in aqueous media: R. Lauricella, et al.; Org. Biomol. Chem.
2, 1304 (2004),
Abstract;
Kinetic study and theoretical analysis of hydroxyl radical trapping and spin adduct decay of alkoxycarbonyl and dialkoxyphosphoryl nitrones in aqueous media: F.A. Villamena, et al.; J. Phys. Chem. (A) 107, 4407 (2003),
2-ethoxycarbonyl-2-methyl-3,4-dihydro-2H-pyrrole-1-oxide: evaluation of the spin trapping properties: G. Olive, et al.; Free Radic. Biol. Med.
28, 403 (2000),
Abstract;
Detection of superoxide anion using an isotopically labeled nitrone spin trap: potential biological applications: H. Zhang, et al.; FEBS Lett.
473, 58 (2000),
Abstract;
Related Products
