Nitric oxide (NO) spin-trapping reagent. Thiol and iron chelator. Inhibits induction of macrophage nitric oxide synthase (NOS). Has been shown to be an inhibitor of the nuclear transcription factor κB (NF-κB).
Product Details
| Alternative Name: | DETC . 3H2O (high purity), Diethyldithiocarbamate . 3H2O (high purity) |
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| Formula: | C5H10NS2 . Na . 3H2O |
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| MW: | 148.3 . 23.0 . 54.0 |
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| CAS: | 20624-25-3 |
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| MI: | 14: 3378 |
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| RTECS: | EZ6550000 |
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| Purity: | ≥99% (Titration) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (20mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Effect of early acute high concentrations of iodide exposure on mitochondrial superoxide production in FRTL cells: X. Yao, et al.; Free Radic. Biol. Med.
52, 1343 (2012),
Abstract;
Evaluation of lipid-based carrier systems and inclusion complexes of diethyldithiocarbamate-iron to trap nitric oxide in biological systems: N. Charlier, et al.; Magn. Reson. Med.
55, 215 (2006),
Abstract;
EPR quantification of vascular nitric oxide production in genetically modified mouse models: J.P. Khoo, et al.; Nitric Oxide
10, 156 (2004),
Abstract;
EPR spectroscopy of common nitric oxide - spin trap complexes: S. Nedeianu & T. Pali; Cell Mol. Biol. Lett.
7, 142 (2002),
Abstract;
Ex vivo EPR detection of nitric oxide in brain tissue: H. Fujii & L.J. Berliner; Magn. Reson. Med.
42, 599 (1999),
Abstract;
Iron diethyldithiocarbamate as spin trap for nitric oxide detection: A.F. Vanin; Methods Enzymol.
301, 269 (1999), Review,
Abstract;
NO-dependent mechanisms of adaptation to hypoxia: I.Y. Malyshev, et al.; Nitric Oxide
3, 105 (1999),
Abstract;
Complexes of Fe2+ with diethyldithiocarbamate or N-methyl-D-glucamine dithiocarbamate as traps of nitric oxide in animal tissues: comparative investigations: V.D. Mikoyan, et al.; Biochim. Biophys. Acta
1336, 225 (1997),
Abstract;
EPR and laser flash photolysis studies of the reaction of nitric oxide with water soluble NO trap Fe(II)-proline-dithiocarbamate complex: S.V. Paschenko, et al.; BBRC
225, 577 (1996),
Abstract;
In vivo spin trapping of nitric oxide generated in the small intestine, liver, and kidney during the development of endotoxemia: a time-course study: G. Wallis, et al.; Shock
6, 274 (1996),
Abstract;
Epr evidence of nitric oxide production by the regenerating rat liver: M. Obolenskaya, et al.; BBRC
202, 571 (1994),
Abstract;
Diethyldithiocarbamate inhibits induction of macrophage NO synthase: A. Mülsch, et al.; FEBS Lett.
321, 215 (1993),
Abstract;
The relationship between L-arginine-dependent nitric oxide synthesis, nitrite release and dinitrosyl-iron complex formation by activated macrophages: A. Vanin, et al.; Biochim. Biophys. Acta
1177, 37 (1993),
Abstract;
Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells: R. Schreck, et al.; J. Exp. Med.
175, 1181 (1992),
Abstract;
NO accounts completely for the oxygenated nitrogen species generated by enzymic L-arginine oxygenation: A. Mülsch, et al.; Biochem. J.
288, 597 (1992),
Abstract;
On-line detection of nitric oxide formation in liquid aqueous phase by electron paramagnetic resonance spectroscopy: P. Mordvintcev, et al.; Anal. Biochem.
199, 142 (1991),
Abstract;
