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CPH . hydrochloride

Spin probe reagent
ALX-430-078-M250 250 mg Inquire for pricing
ALX-430-078-M050 50 mg Inquire for pricing
ALX-430-078-M010 10 mg Inquire for pricing
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Effective, cell permeable and non-toxic spin probe for the detection of superoxide radical and peroxynitrite, both in vitro and in vivo. Resistant to reduction by vitamin C and thiols.

Product Details

Alternative Name:1-Hydroxy-3-carboxy-2,2,5,5-tetramethylpyrrolidine . HCl
Formula:C9H17NO3 . HCl
CAS:92416-28-9 (non-salt)
Purity:≥99% (EPR)
Appearance:White to off-white solid.
Solubility:Soluble in DMSO, 100% ethanol, methanol or water.
Shipping:Blue Ice
Long Term Storage:-20°C
Use/Stability:Prepare fresh solutions daily before use and store 4-6 hours on ice under a nitrogen/argon flow.
Oxygen will lead to oxidation and therefore it is strongly recommended to dissolve the probe in water and not in organic solvents such as DMSO, ethanol o
Regulatory Status:RUO - Research Use Only
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Product Literature References

Sex differences in blood pro-oxidant status and platelet activation in children admitted with respiratory syncytial virus bronchiolitis: a pilot study: I.T. De Jacobis, et al.; Ital. J. Pediatr. 46, 29 (2020), Abstract; Full Text
Use of Electron Paramagnetic Resonance in Biological Samples at Ambient Temperature and 77 K: H.B. Eajaili, et al.; J. Vis. Exp. e58461 (2019), Abstract;
An altered redox balance and increased genetic instability characterize primary fibroblasts derived from Xeroderma pigmentosum group A patients: E. Parlanti, et al.; Mutat. Res. 782, 34 (2015), Application(s): Measurement of ROS levels, Abstract;
EPR Detection of Cellular and Mitochondrial Superoxide Using Cyclic Hydroxylamines: S.I. Dikalov, et al.; Free. Radic. Res. 45, 417 (2011), Application(s): Electron paramagnetic resonance (EPR) spectroscopy, Abstract; Full Text
Therapeutic targeting of mitochondrial superoxide in hypertension: A.E. Dikalova, et al.; Circ. Res. 107, 106 (2010), Abstract;
Indoxyl sulfate induces complex redox alterations in mesangial cells: A.K. Gelasco & J.R. Raymond; Am. J. Physiol. Renal Physiol. 290, F1551 (2006), Abstract;
Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase: N. Kuzkaya, et al.; Biochem. Pharmacol. 70, 343 (2005), Abstract;
Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase: N. Kuzkaya, et al.; J. Biol. Chem. 278, 22546 (2003), Abstract; Full Text
Noninvasive diagnostic tool for inflammation-induced oxidative stress using electron spin resonance spectroscopy and an extracellular cyclic hydroxylamine: S.I. Dikalov, et al.; Arch. Biochem. Biophys. 402, 218 (2002), Abstract;
A new approach for extracellular spin trapping of nitroglycerin-induced superoxide radicals both in vitro and in vivo: B. Fink, et al.; Free Radic. Biol. Med. 28, 121 (2000), Abstract;
Comparison of glyceryl trinitrate-induced with pentaerythrityl tetranitrate-induced in vivo formation of superoxide radicals: effect of vitamin C: S. Dikalov, et al.; Free Radic. Biol. Med. 27, 170 (1999), Abstract;
Quantification of superoxide radicals and peroxynitrite in vascular cells using oxidation of sterically hindered hydroxylamines and electron spin resonance: S. Dikalov, et al.; Nitric Oxide 1, 423 (1997), Abstract;
Spin trapping of superoxide radicals and peroxynitrite by 1-hydroxy-3- carboxy-pyrrolidine and 1-hydroxy-2,2,6, 6-tetramethyl-4-oxo-piperidine and the stability of corresponding nitroxyl radicals towards biological reductants: S. Dikalov, et al.; BBRC 231, 701 (1997), Abstract;

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