Cyclic hydroxylamine spin probe for in vivo, intraperitoneal and intravenous injections. Lifetime of more than 4 hours in blood plasma, in cells and tissue. Allows quantitative measurements of extracellular O2•– and quantification of intracellular O2•– in cells and tissue samples and in vivo O2•– detection.
Product Details
| Alternative Name: | 1-Hydroxy-2,2,6,6-tetramethylpiperidin-4-yl-trimethylammonium chloride . HCl |
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| Formula: | C12H26N2O . 2HCl |
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| MW: | 214.4 . 72.9 |
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| Purity Detail: | Paramagnetic impurities ≤0.01% (EPR). |
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| Appearance: | Colorless crystalline solid. |
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| Solubility: | Soluble in water, methanol or 100% ethanol. |
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| Shipping: | Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Handling: | Protect from moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Use of Electron Paramagnetic Resonance in Biological Samples at Ambient Temperature and 77 K: H.B. Eajaili, et al.; J. Vis. Exp. e58461 (2019),
Abstract;
LRRC8A channels support TNFα-induced superoxide production by Nox1 which is required for receptor endocytosis: H. Choi, et al.; Free Radic. Biol. Med.
101, 413 (2016),
Abstract;
EPR detection of cellular and mitochondrial superoxide using cyclic hydroxylamines: S.I. Dikalov, et al.; Free Rad. Res.
45, 417 (2011),
Abstract;
Measurement of reactive oxygen species in cardiovascular studies: S. Dikalov, et al.; Hypertension
49, 717 (2007),
Abstract;
Mitochondrial redox cycling of mitoquinone leads to superoxide production and cellular apoptosis: A.K. Doughan & S.I. Dikalov; Antioxid. Redox Signal.
9, 1825 (2007),
Abstract;
Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction: T.J. Guzik, et al.; J. Exp. Med.
204, 2449 (2007),
Abstract;
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Role of extracellular superoxide dismutase in hypertension: M.C. Gongora, et al.; Hypertension
48, 473 (2006),
Abstract;
Full Text
