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Spin trapping reagent
ALX-430-119-M050 50 mg 250.00 USD
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Beside DEPMPO (Prod. No. ALX-430-093), most efficient spin trap for the in vitro and in vivo detection of O-, N-, S-, and C-centered free radicals. Has a longer life-time than DMPO (Prod. No. ALX-430-090). More lipophilic (Kp=2.1) than DEPMPO.

Product Details

Alternative Name:5-(Diisopropoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide
Purity:≥98% (TLC, 1H- and 13C-NMR)
Appearance:Off-white to pale yellow low melting solid.
Solubility:Soluble in water, 100% ethanol or methylene chloride.
Shipping:Blue Ice
Short Term Storage:-20°C
Long Term Storage:-80°C
Handling:Protect from light. Very hygroscopic. Handle under an inert atmosphere.
Regulatory Status:RUO - Research Use Only
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Product Literature References

The Role of Chelating Agents and Amino Acids in Preventing Free Radical Formation in Bleaching Systems: J. Hodes, et al.; Free Radic. Biol. Med. 129, 194 (2018), Abstract;
Study of natural anthraquinone colorants by EPR and UV/vis spectroscopy: Z. Machatova, et al.; Dyes Pigm. 132, 79 (2016), Application(s): Cell culture,
Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus: Y. Shi, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol. 304, R343 (2013), Application(s): Electron paramagnetic resonance (EPR) spectroscopy, Abstract; Full Text
The line asymmetry of electron spin resonance spectra as a tool to determine the cis:trans ratio for spin-trapping adducts of chiral pyrrolines N-oxides: the mechanism of formation of hydroxyl radical adducts of EMPO, DEPMPO, and DIPPMPO : M. Culcasi, et al.; Free Radic. Biol. Med. 40, 1524 (2006), Abstract;
5-(Diisopropoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide, DIPPMPO, a crystalline analog of the nitrone DEPMPO: synthesis and spin trapping properties: F. Chalier & P. Tordo; J. C. S. Perkin Trans. II 2002, 2110 (2002), Full Text

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