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Genomics









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Clear Results With Innovative Nucleic Acid Labeling

Enabling Solutions for Genomics Analysis

Enzo Life Sciences is a recognized pioneer and innovator of life sciences tools, backed by patented DNA and RNA labeling chemistries for genomics research and development. The pillar of our molecular biology portfolio is our comparative genomic hybridization (aCGH) kit, a powerful platform for detecting DNA copy number gains and losses associated with chromosome abnormalities. aCGH provides a greater understanding and characterization of genetic disorders, cancers, and other genomic aberrations.

Supporting our aCGH kits are a variety of everyday-use molecular biology products designed to maximize the quantity and quality of data generated from your valuable samples. These include RNA and DNA amplification kits, as well as labeling systems and modified nucleotides designed for creating biotin- or fluorophore-labeled nucleic acid probes for a variety of applications and detection platforms. The products have been specifically designed to provide optimal performance in nick translation reactions or with Agilent® arrays.

To further support your analysis of chromosomal and genomic structure Enzo Life Sciences provides all the materials needed (dye- or biotin-labeled nucleotides, nick translation kits, hybridization solutions and development chemistry) to generate the highest quality fluorescence or chromogenic in situ hybridizations experiments.

 

Microarray Labeling

Enable Proven, Consistent array CGH

CYTAG™ CGH Labeling Kit

Array-based comparative genomic hybridization (aCGH) is a powerful tool for detecting gene copy number gains and losses associated with chromosome abnormalities. Detecting chromosomal aberrations by array CGH is faster, more robust and provides superior results over other technologies such as FISH and G-banding karyotyping, thus providing a greater understanding of the role of chromosomal changes in genetic diseases and cancers. Enzo superior labeling technology yields the industry’s most consistent CGH results.


CYTAG™ TotalCGH Labeling Kit

For a complete solution to prepare DNA for CGH+SNP analysis, Enzo offers the CYTAG™ TotalCGH Labeling Kit. Included in the kit are restriction enzymes AluI and RsaI for DNA digestion, the CYTAG™ CGH Labeling kit for superior labeling, and PCR & Gel Clean-up columns for purifying labeled DNA.

Gene Expression and Transcript Analysis

BIOARRAY® Amplification & Labeling Kits

Enzo’s BIOARRAY® RNA Amplification & Labeling kits offer labeling solutions for biotin-based gene expression microarrays. Due to greater biotin incorporation and brighter signal, BIOARRAY® RNA labeling is the best choice for routine GeneChip® analysis.


Analyze Limiting Quantities of Total RNA

Don’t let the quantity of starting material limit your assay. Our BIOARRAY® Low Input RNA Amplification and Biotin Labeling System generates sufficient biotin labeled aRNA from as little as 20ng of total input RNA.


In situ Hybridization & FISH

PATHO-GENE® & BIOPROBE® Virus Detection Assays

PATHO-GENE® Human Papillomavirus in situ typing assays for sensitive detection of pathogen-expressed genes from fresh or FFPE tissue sections
The assays employ separate mixtures of biotin-labeled Human Papillomavirus (HPV)-specific probes to detect and identify HPV/DNA-infected biopsy tissue sections. The identifying probes are HPV types 6/11 (benign lesions), 16/18 (cervical intraepithelial neoplasia [CIN] and carcinoma in situ [CIS]), or 31/33/51 (condyloma or cervical intraepithelial neoplasia [CIN] and carcinoma in situ [CIS]).


FLOWSCRIPT® HPV E6/E7 Assay

Flow cytometry based assay for the single cell detection of mRNAs for HPV oncoproteins E6 and E7

The assay employs a novel in situ hybridization technique utilizing a cocktail of probes specific to multiple sites within the E6 and E7 genes to ensure the detection of mRNA transcripts associated with the most prevalent high risk HPV genotypes.

 

Labeling & Detection Systems

Digoxigenin Labeling & Detection
Digoxigenin NHS ester
Digoxigenin-dUTP, alkali-stable
Digoxigenin-UTP, alkali-stable
Digoxigenin polyclonal antibody

BIOPROBE® Labeling Systems
BIOPROBE® Nick Translation Systems
BIOPROBE® Random Primed Labeling Systems

Hybridization Reagents & Buffers

Detection Systems
SIMPLYSENSITIVE® In Situ Detection Systems
ULTRASENSITIVE® Enhanced In Situ Detection Systems

FISH Solutions

Enzo offers fluorescent dye-dUTPs and Nick Translation DNA Labeling System for making FISH probes. This direct approach provides a simple and efficient method to label DNA for FISH, suitable for a wide range of molecular biology and cytogenetics applications.

 

PCR & qPCR

AMPIPROBE™ Nucleic Acid Detection

AMPIPROBE™ incorporates Enzo’s proprietary primer design in a unique qPCR platform that enables sensitive detection of nucleic acids. AMPIPROBE™ assay kits, a low-cost alternative in a price-sensitive market, are designed for clinically relevant targets. Enzo’s landmark AMPIPROBE™ assay, the AMPIPROBE™ HCV assay kit, is a sensitive qPCR assay to measure Hepatitis C viral load.

AMPIGENE® PCR and qPCR Solutions

Enzo offers solutions for both traditional PCR and qPCR. Our AMPIGENE® Taq Mixes and RT-PCR Kit are optimized for standard PCR experiments and come in a variety of flexible formats to enable easy PCR and RT-PCR. In addition, we offer AMPIGENE® qPCR Kits and Mixes for both dye-based and probe-based real-time PCR. Enhanced buffers with stabilizers prevent the formation of primers/dimers to ensure sensitive and specific results for your qPCR and RT-qPCR applications.

CYGREEN® Nucleic Acid Dye

CYGREEN® Nucleic acid dye can be used for gel staining, higher sensitivity qPCR, and melt curve analysis. It has excitation/emission spectra similar to commonly used qPCR dyes and can be substituted in to increase sensitivity and reduce cost.


DNA Purification

PCR & Gel clean-up columns

PCR & Gel clean-up columns use silica membrane technology in a mini spin column format to deliver easy and efficient DNA purification from PCR products, agarose gels, and labeling reactions.

  • High recoveries for fragments down to 50 bp
  • Small elution volume down to 15 µl
  • Binding buffer with pH indicator
  • Validated for use with CGH labeling kit

BIOARRAY™ cDNA purification kit

The cDNA purification kit provides a fast, efficient and convenient method for purification of double stranded cDNA and removes salts, proteins, nucleotides and small oligos from the upstream enzymatic reactions.

  • Improved formulations of binding buffer and wash solution allow higher yield of purified cDNA product
  • Small elution volume down to 6 µL
  • Purifies a maximum of 5 µg cDNA material ranging in size from 75 bp to 23 kb.

Related Literature and Documents

New Products

CYTAG™ TotalCGH Labeling kit
Complete kit to digest and label DNA for CGH+SNP arrays
Digoxigenin-dUTP, alkali-stable
Digoxigenin-labeled nucleotide suitable for non-radioactive labeling of DNA probes
Digoxigenin-UTP, alkali-stable
Digoxigenin-labeled nucleotide suitable for non-radioactive labeling of RNA probes
AMPIPROBE™ HCV assay kit
Sensitive and unique qPCR assay for quantifying HCV viral load
N6-methyladenosine monoclonal antibody (17-3-4-1)
Used to identify and purify methylated RNA and ssDNA.

Featured Literature

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