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E-64-D

Calpain and cathepsin inhibitor
 
BML-PI107-0001 1 mg 70.00 USD
 
BML-PI107-0005 5 mg 290.00 USD
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Cell-permeable, ethyl ester of E-64-c. The ester is hydrolyzed by intracellular esterases to produce E-64-c. Inhibits calpain and cathepsins B, H, and L. Inhibits degradation of autophagic cargo inside autophagolysosomes.

Product Specification

Alternative Name:2S,3S-trans-(Ethoxycarbonyloxirane-2-carbonyl)-L-leucine-(3-methylbutyl) amide, Aloxistatin
 
Formula:C17H30N2O5
 
MW:342.4
 
CAS:88321-09-9
 
Purity:≥98% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in 100% ethanol (>10mg/ml) or DMSO (20mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 2 months.
 
BML-PI107 structure
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BML-PI107 structure

Product Literature References

Mutants of collagen-specific molecular chaperone Hsp47 causing osteogenesis imperfecta are structurally unstable with weak binding affinity to collagen: S. Ito, et al; Biochem. Biophys. Res. Commun. 469, 437 (2016), Application(s): Cell culture, Abstract;
Proteomic analysis of silenced cathepsin B expression suggests non-proteolytic cathepsin B functionality: F.C. Sigloch, et al.; Biochem. Biophys. Acta 1863, 2700 (2016), Application(s): Cell culture; inhibition experiments on U2OS cell line (ATCC), Abstract;
Fatty acids increase adiponectin secretion through both classical and exosome pathways: V. DeClercq, et al.; Biochim. Biophys. Acta 1851, 1123 (2015), Application(s): Cell Culture, Abstract;
Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease: J. Peters, et al.; Biochem. Biophys. Res. Commun. 457, 334 (2015), Application(s): Cell Culture, Abstract;
Mast Cell Subsets and Their Functional Modulation by the Acanthocheilonema viteae Product ES-62: D.H. Ball, et al.; J. Parasitol. Res. 2013, 961268 (2013), Abstract; Full Text
Inhibition of calpain in intact platelets by the thiol protease inhibitor E-64d: E. B. McGowan et al.; Biochem. Biophys. Res. Commun. 158, 432 (1989), Abstract;
Efficient synthetic method for ethyl (+)-(2S,3S)-3-[(S)-3-methyl- 1-(3-methylbutylcarbamoyl)butylcarbamoyl]-2-oxiranecarb oxylate (EST), a new inhibitor of cysteine proteinases: M. Tamai et al.; Chem. Pharm Bull. (Tokyo) 35, 1098 (1987), Abstract;

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