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OMNICATHEPSIN® fluorogenic substrate

BML-P139-0010 10 mg 115.00 USD
BML-P139-0050 50 mg 297.00 USD
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Replaces Prod. #: ALX-260-131

Fluorogenic substrate cleaved by plasma kallikrein and kallikrein 8, but not plasmin; by papain; and by most cathepsins (cathepsins B, C/DPP-I, F, K/O2, L, L2/V, O, S, and X/Z). Ex.: 380 nm, Em.: 460 nm, although the following Ex/Em can also be used: 355,375/440,450. This substrate is useful for inhibitor screening and kinetic analysis. Also available: fluorogenic calibration standard AMC (BML-KI144).

Product Details

Alternative Name:Z-FR-AMC, Z-Phe-Arg-AMC
Sequence:Z-FR-AMC, Z-Phe-Arg-AMC . HCl [Z=Cbz=Benzyloxycarbonyl; AMC=7-amino-4-methylcoumarin]
Formula:C33H36N6O6 . HCl
Shipping:Blue Ice
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only

Product Literature References

Cathepsin S Contributes to Lung Inflammation in Acute Respiratory Distress Syndrome: M.C. McKelvey, et al.; Am. J. Respir. Crit. Care Med. 1164, 1631OC (2022), Abstract;
Modulation of Cystatin C in Human Macrophages Improves Anti-Mycobacterial Immune Responses to Mycobacterium tuberculosis Infection and Coinfection With HIV: D. Pires, et al.; Front. Immunol. 18, 742822 (2021), Abstract;
Nrf2 activation induces mitophagy and reverses Parkin/Pink1 knock down-mediated neuronal and muscle degeneration phenotypes: S. Gumeni, et al.; Cell Death Dis. 12, 41419 (2021), Abstract;
Biological Evaluation and In Silico Study of Benzoic Acid Derivatives from Bjerkandera adusta Targeting Proteostasis Network Modules: K. Georgousaki, et al.; Molecules 25, 666 (2020), Application(s): Cathepsin B, L enzymatic activity in human foreskin fibroblasts (BJ) lysates., Abstract; Full Text
Cell penetrable, clickable and tagless activity-based probe of human cathepsin L: D. Dana, et al.; Bioorg. Chem. 85, 505 (2019), Application(s): Activity assay, Abstract;
Skeletal Muscle Lysosomal Function via Cathepsin Activity Measurement: K. Gumpper, et al.; Methods Mol. Biol. 1854, 35 (2019), Abstract;
Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply: H. Zhang, et al.; Autophagy 14, 1779 (2018), Abstract;
Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs: J. Vallecillo-Hernandez, et al.; Sci. Rep. 8, 3593 (2018), Abstract; Full Text
Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients: C. Valdez, et al.; Hum. Mol. Genet. 26, 4861 (2017), Abstract; Full Text
Evaluation of trypanocidal activity of combinations of anti-sleeping sickness drugs with cysteine protease inhibitors: D. Steverding, et al.; Exp. Parasitol. 151, 28 (2015), Application(s): Assay, Abstract;
Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.) 50, 10875 (2014), Abstract;
Cathepsin B is up-regulated and mediates extracellular matrix degradation in trabecular meshwork cells following phagocytic challenge: K. Porter, et al.; PLoS One 8, e68668 (2013), Abstract; Full Text
Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity: M. Li, et al.; J. Biol. Chem. 288, 35769 (2013), Abstract; Full Text

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