Selective inhibitor of calpain, 100-fold selective for calpain over proteasome.
Product Details
| Sequence: | Z-Leu-Leu-CHO |
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| MW: | 362.5 |
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| Source: | Synthetic. |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO or ethanol. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C or colder for up to 1 year. Store solutions at –20°C or colder for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A calpain inhibitor protects against fractalkine production in lipopolysaccharide-treated endothelial cells: J. Jang, et al.; Kidney Res. Clin. Pract.
36, 224 (2017),
Abstract;
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The effect of ARC ablation on skeletal muscle morphology, function, and apoptotic signaling during aging: K. Vorobej, et al.; Exp. Gerontol.
101, 69 (2017),
Abstract;
Data on skeletal muscle apoptosis, autophagy, and morphology in mice treated with doxorubicin: T.L. Campbell, et al.; Data Brief
7, 786 (2016),
Application(s): Measured calpain activity in mixed gastrocnemius homogenates,
Abstract;
Differential apoptosis-related protein expression, mitochondrial properties, proteolytic enzyme activity, and DNA fragmentation between skeletal muscles: E.M. McMillan, et al.; Am. J. Physiol. Regul. Integr. Comp. Physiol.
300, R531 (2011),
Abstract;
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