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Cathepsin K drug discovery kit

BML-AK430-0001 96 wells 633.00 USD
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The Cathepsin K Drug Discovery Kit is a complete assay system designed to screen inhibitors of cathepsin K. Using a convenient microplate format, cathepsin K activity is monitored fluorimetrically using the substrate provided in the kit.

Product Details

Applications:Fluorescent detection, HTS
Activity assay
Application Notes:Screening potential activators or inhibitors of cathepsin K using the recombinant enzyme supplied in the kit. This kit is NOT suitable for measuring cathepsin K activity in biological samples
Use/Stability:The enzyme component should be thawed as close to the time of use as is possible, and held on ice while in use. The enzyme can be frozen and thawed up to 5 times, but care should be taken to minimize both the time the enzyme spends on ice, and the number of times it is frozen and thawed. Do not hold the diluted enzyme at assay temperature (e.g 37°C) for an extended time before starting the assay.
Handling:Avoid freeze/thaw cycles.
Shipping:Dry Ice
Long Term Storage:-80°C
Contents:Cathepsin K (human) (recombinant), AMC substrate, AMC calibration standard, inhibitor, assay buffer, 1/2-volume white microplate.
UniProt ID:P43235
Regulatory Status:RUO - Research Use Only

Product Literature References

Alpha-1 antitrypsin inhibits RANKL-induced osteoclast formation and functions: M.A. Akbar, et al.; Mol. Med. 23, 57 (2017), Abstract; Full Text

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Cathepsin K assay buffer 

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