Replaces Prod. #: ALX-260-038
Cell-permeable, peptide aldehyde inhibitor of calpain and other neutral cysteine proteases. Potent inhibitor of cathepsin L (Ki=0.6nM) and cathepsin B (Ki=100nM).
Product Details
| Alternative Name: | ALLM, Ac-LLM-CHO, Calpain inhibitor II |
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| Sequence: | N-Acetyl-Leu-Leu-Met-H |
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| Formula: | C19H35N3O4S |
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| MW: | 401.6 |
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| CAS: | 110115-07-6 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | White to off-white powder. |
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| Solubility: | 5mg/ml soluble in 100% ethanol, methanol or DMSO |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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General Literature References
Comparison of the effect of calpain inhibitors on two extralysosomal proteinases: the multicatalytic proteinase complex and m-calpain.: M.E. Figueiredo-Pereira et al.; J. Neurochem.
62, 1989 (1994),
Abstract;
Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids.: M. Orlowski et al.; Biochemistry
32, 1563 (1993),
Abstract;
Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex.: A. Vinitsky et al.; Biochemistry
31, 9421 (1992),
Abstract;
Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins.: T. Sasaki et al.; J. Enzyme Inhib.
3, 195 (1990),
Abstract;
