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Epigenetics

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Browse our complete Epigenetics range

Comprehensive Tools for Epigenetic Modification

Unravel the Code Within the Code

Epigenetics can be defined as the structural adaptation of chromosomal regions so as to register, signal or perpetuate altered activity states. A variety of chromatin-altering post-translational modifications (PTMs) to histone proteins including acetylation, methylation, and ubiquitinylation, as well as direct modifications to DNA, are known to turn gene transcription off or on. To date, acetylation/deacetylation of histone lysine residues, and methylation of DNA have proven to be of greatest clinical significance amongst epigenetic PTMs.

The approval of anti-cancer drugs such as Vorinostat and Decitabine, targeting Histone Deacetylases (HDACs) and DNA Methyltransferases (DNMTs), respectively, as well as pharma development pipelines targeting PTM regulating enzymes, are evidence that reprograming gene expression on an epigenetic level holds great clinical promise.

 

Complete Toolbox for Epigenetics Research

Sample Extraction Kits

Rapid Extraction Kits for Epigenetic Workflows

Guarantee reproducible, high-yield isolation of histones, nuclear proteins and DNA

  • Rapid, reliable methods to isolate samples to for downstream applications.
  • Available in different formats with additional features to fit application.

 

Histone Post-translational Modifications

Solutions For Screening Epigenetic Regulators

For over a decade, the Fluor de Lys® deacetylase assay platform has freed researchers from cumbersome protocols for screening HDAC & Sirtuin activity. Our high-quality chemiluminescent, fluorescent, and colorimetric assays deliver more high-quality hits, and are backed by a broad panel of characterized inhibitors and PTM-specific antibodies for ubiquitinylation, sumoylation, methylation, acetylation, and phosphorylation.

 

Active Enzymes & Drug Discovery Assays

Convenient screening formats, featuring Fluor de Lys HDAC & Sirtuin assays, transferase & demethylase assays, and high-activity enzymes.

Small Molecules & Compound Libraries

Benchmark against known epigenetic modulators.

PTM-specific Antibodies

Detect acetylation, methylation, ubiquitinylation and more with high-quality antibodies backed by our Worry-Free program.

Ubiquitin & Ubl Signaling

Browse our industry-leading portfolio of active enzymes, antibodies, and kits for ubiquitinylation and SUMOylation.

 

DNA Modifications

Convenient Kits for Sample Conversion and Detection

DNA methylation can alter gene expression, cell differentiation and often results in unidirectional changes to genomic DNA. Its involvement in so many cellular processes means errors resulting in abnormal DNA methylation patterns can lead to disease. Expanding our expertise in epigenetic modification analysis, Enzo Life Sciences now offers a portfolio of products that enable detection of DNA methylation.

 

Sample conversion

5-mC and 5-hmC Conversion

High-efficiency Conversion of 5-mC and 5-hmC DNA for the Truest Downstream Analysis

DNA Methylation Detection

Real-Time PCR Based Detection

BioPanel™ DNA Methylation Detection Kit for Human Pluripotent Stem Cells

ELISA-Based Detection

5-mC and 5-hmC DNA ELISA Kits

Colorimetric Assay Based Detection

DNMT Colorimetric Drug Discovery Kit

Rapid, sensitive, and simple colorimetric DNMT activity/inhibition kit.

Related Literature and Documents

Featured Literature

Product Flyers
Epigenetics - Unravel the Code Within the Code
Epigenetics - Unravel the Code Within the Code 22-Aug-13
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Catalogs
Product Guide Epigenetics
Product Guide Epigenetics 23-May-13
Download as PDF
 
 

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