Product Details
| Alternative Name: | Histone H3-K4 methyltransferase |
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| MW: | ~40.7kDa. |
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| Source: | Produced in E. coli. |
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| EC: | 2.1.1.43 |
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| UniProt ID: | Q8WTS6 |
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| Concentration: | 1mg/ml |
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| Formulation: | Liquid. In 50mM TRIS-HCl, pH 7.5, containing 0.2M sodium chloride, 5mM DTT and 20% glycerol. |
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| Purity: | ≥95% (SDS-PAGE) |
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| Endotoxin Content: | <1.0EU/µg protein (LAL test) |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Handling: | Avoid freeze/thaw cycles. |
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| Scientific Background: | Histone methyltransferase that transfers methyl groups to Lys4 of histone H3, in complex with S-adenosyl-L-methionine. |
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| Regulatory Status: | RUO - Research Use Only |
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10% SDS-PAGE of human SET7/9 (Prod. No. ALX-201-178).
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Product Literature References
Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search: H. Ding, et al.; Molecules
23, E567 (2018),
Abstract;
Full Text
Miniaturization of High-Throughput Epigenetic Methyltransferase Assays with Acoustic Liquid Handling: B. Edwards, et al.; J. Lab. Autom.
21, 208 (2016),
Abstract;
Modulations of DNA Contacts by Linker Histones and Post-translational Modifications Determine the Mobility and Modifiability of Nucleosomal H3 Tails: A. Stutzer, et al.; Mol. Cell
61, 247 (2016),
Abstract;
Development of homogeneous nonradioactive methyltransferase and demethylase assays targeting histone H3 lysine 4: N. Gauthier, et al.; J. Biomol. Screen.
17, 49 (2012),
Abstract;
Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production: K. Bonham, et al.; FEBS J.
277, 2096 (2010),
Abstract;
Full Text
Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet: T. Kwon, et al.; EMBO J.
22, 292 (2003),
Abstract;
General Literature References
Structure and catalytic mechanism of the human histone methyltransferase SET7/9: B. Xiao, et al.; Nature
421, 652 (2003),
Abstract;
