Product Details
| Alternative Name: | Aurora Kinase A |
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| MW: | 50kDa |
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| Source: | Produced in Sf9 insect cells. Human recombinant aurora A kinase (aa 2-403) is fused at the N-terminus to a His-tag. Produced in a baculovirus expression system. |
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| UniProt ID: | O14965 |
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| Formulation: | Liquid. In 40 mM Tris, pH 8.0, containing 110mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, and 3 mM DTT. |
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| Application Notes: | Useful for kinetic studies and drug discovery. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Handling: | Avoid freeze/thaw cycles. |
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| Scientific Background: | Aurora kinases control chromatid segregation and their expression is elevated in many human cancers making them targets of interest of anti-cancer therapeutics. Ectopic overexpression of aurora kinase A in mammalian cells induces centrosome amplification, chromosome instability, and oncogenic transformation, a phenotype characteristic of loss-of-function mutations of p53. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
pERK 1/2 inhibit Caspase-8 induced apoptosis in cancer cells by phosphorylating it in a cell cycle specific manner: R. Mandal, et al.; Mol. Oncol.
8, 232 (2014),
Abstract;
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