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Aurora A (human), (recombinant) (His-tag)

BML-SE406-0010 10 µg 489.00 USD
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Product Details

Alternative Name:Aurora Kinase A
Source:Produced in Sf9 insect cells. Human recombinant aurora A kinase (aa 2-403) is fused at the N-terminus to a His-tag. Produced in a baculovirus expression system.
UniProt ID:O14965
Formulation:Liquid. In 40 mM Tris, pH 8.0, containing 110mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 20% glycerol, and 3 mM DTT.
Application Notes:Useful for kinetic studies and drug discovery.
Shipping:Dry Ice
Long Term Storage:-80°C
Handling:Avoid freeze/thaw cycles.
Scientific Background:Aurora kinases control chromatid segregation and their expression is elevated in many human cancers making them targets of interest of anti-cancer therapeutics. Ectopic overexpression of aurora kinase A in mammalian cells induces centrosome amplification, chromosome instability, and oncogenic transformation, a phenotype characteristic of loss-of-function mutations of p53.
Regulatory Status:RUO - Research Use Only

Product Literature References

pERK 1/2 inhibit Caspase-8 induced apoptosis in cancer cells by phosphorylating it in a cell cycle specific manner: R. Mandal, et al.; Mol. Oncol. 8, 232 (2014), Abstract; Full Text

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