For a larger pack size, please see Prod. No.
ALX-746-070.
CpG oligodeoxynucleotide (Type C) with phosphorothioate backbone. Specific ligand for human and mouse TLR9 (Toll-like receptor 9).
Product Details
| Sequence: | 5’-tcgtcgttttcggcgcgcgccg-3’(bold letters indicate active, immune-stimulatory portions of CpG sequence, un-bolded letters indicate phosphorothioate linkage) |
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| MW: | 7068 (ammonium salt) |
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| Source: | Synthetic. |
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| Formulation: | Lyophilized. Sterile. |
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| Purity Detail: | Activity and endotoxin tested - TLRGRADE®. |
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| Endotoxin Content: | <0.002 EU/µg (LAL test; BioWhittaker) |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Use/Stability: | Aqueous stock solution is stable for 1 day when stored at +4°C. |
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| Handling: | Protect from light. For maximum product recovery after thawing, centrifuge the vial before opening the cap. After reconstitution, prepare aliquots and store at -20°C. |
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| Technical Info/Product Notes: | Includes 1 vial of ddWater (endotoxin-free) (Prod. No. ALX-505-008).
For the inactive control compound, please see Prod. No. ALX-746-256. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Human Langerhans cells selectively activated via Toll-like receptor 2 agonists acquire migratory and CD4+T cell stimulatory capacity: M. Peiser, et al.; J. Leukoc. Biol.
83, 1118 (2008),
Abstract;
General Literature References
Combined treatment of CpG-oligodeoxynucleotide with Nutlin-3 induces strong immune stimulation coupled to cytotoxicity in B-chronic lymphocytic leukemic (B-CLL) cells: P. Secciero, et al.; J. Leukoc. Biol.
83, 434 (2008),
Abstract;
Eosinophils induce DC maturation, regulating immunity: R. Lotfi & M.T. Lotze; J. Leukoc. Biol.
83, 546 (2008),
Abstract;
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