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Guanosine 5’-O-(3-thiotriphosphate) . tetralithium salt

Non-hydrolyzable GTP analog
ALX-480-056-M001 1 mg 70.00 USD
ALX-480-056-M005 5 mg 230.00 USD
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Replaces Prod. #: BML-G305

  • Used to obtain crystal structures of GTPases and measure their stability in presence of ligands
Guanosine 5’-O-(3-thiotriphosphate) (GTP-g-S) is a non-hydrolyzable analog of guanosine 5’-O-triphosphate (GTP) (Prod. No. ALX-480-057). GTP-g-S stimulates inositol trisphosphate formation in membranes.

Product Details

Alternative Name:GTP-γ-S . 4Li
Formula:C10H12N5O13P3S . 4Li
MW:535.2 . 27.8
Purity:≥85% (HPLC)
Appearance:White to off-white solid.
Solubility:Soluble in water (25mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

A functional role for GTP-binding proteins in synaptic vesicle cycling: S.D. Hess, et al.; Science 259, 1169 (1993), Abstract;
G proteins: transducers of receptor-generated signals: A.G. Gilman; Ann. Rev. Biochem. 56, 615 (1987), Abstract;
Guanosine 5'-O-(thiotriphosphate)-dependent inositol trisphosphate formation in membranes is inhibited by phorbol ester and protein kinase C: S. Orellana, et al.; J. Biol. Chem. 262, 1638 (1987), Abstract; Full Text

General Literature References

Small conductance chloride channels in acinar cells from the rat mandibular salivary gland are directly controlled by a G-protein: D.K. Martin; Biochem. Biophys. Res. Commun. 192, 1266 (1993), Abstract;
Evidence of GTP-binding protein regulation of phospholipase A2 activity in isolated human platelet membranes: S.T. Silk, et al.; J. Biol. Chem. 264, 21466 (1989), Abstract;

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