Small molecule GTPase inhibitor targeting Dynamin-1, Dynamin-2 and Drp1 (mitochondrial Dynamin). Noncompetitive inhibitor of Dynamin GTPase activity. Blocks Dynamin-dependent endocytosis in cells (including neurons). Fast acting (seconds). Strong, dose dependent block of the traffic and accumulation of transferrin with 80µM dynasore (IC50 = 15µM). Has also been shown to block human papillomavirus type 16 (HPV16) and bovine papillomavirus type 1 (BPV1) (pseudovirions) infections.
Product Details
| Formula: | C18H14N2O4 |
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| MW: | 322.3 |
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| CAS: | 304448-55-3 |
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| Purity: | ≥98% (HPLC, TLC) |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in 100% ethanol (1mg/ml) or DMSO (10mg/ml); insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Short Term Storage: | -20°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stock solutions are stable for up to 3 months when stored at -20°C. |
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| Handling: | Protect from light. Keep under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
GM101 in Combination with Histone Deacetylase Inhibitor Enhances Anti-Tumor Effects in Desmoplastic Microenvironment: H.G. Chang, et al.; Cells
10, 2811 (2021),
Application(s): U343 cells treatment,
Abstract;
Full Text
Lysosomal dysfunction and autophagy blockade contribute to MDMA-induced neurotoxicity in SH-SY5Y neuroblastoma cells: I.H. Li, et al.; Chem. Res. Toxicol.
33, 903 (2020),
Abstract;
The apical protein Apnoia interacts with Crumbs to regulate tracheal growth and inflation: K. Skouloudaki, et al.; PLoS Genet.
15, e1007852 (2019),
Abstract;
Full Text
Bacterial LPX motif-harboring virulence factors constitute a species-spanning family of cell-penetrating effectors: S. Norkowski, et al.; Cell. Mol. Life Sci.
75, 2273 (2018),
Abstract;
c-jun N-terminal kinase attenuates TNFα signaling by reducing Nox1-dependent endosomal ROS production in vascular smooth muscle cells: H. Choi, et al.; Free Radic. Biol. Med.
86, 219 (2015),
Abstract;
PKCε-mediated c-Met endosomal processing directs fluctuant c-Met-JNK-paxillin signaling for tumor progression of HepG2: C.T. Hu, et al.; Cell. Signal.
27, 1544 (2015),
Application(s): Cell Culture,
Abstract;
Dynasore, a dynamin inhibitor, inhibits Trypanosoma cruzi entry into peritoneal macrophages: E.S. Barrias, et al.; PLoS One
5, e7764 (2010),
Abstract;
Full Text
Elimination of a bacterial pore-forming toxin by sequential endocytosis and exocytosis: M. Husmann, et al. ; FEBS Lett.
583, 337 (2009),
Abstract;
Use of Dynasore, the Small Molecule Inhibitor of Dynamin, in the Regulation of Endocytosis: T. Kirchhausen, et al.; Meth. Enzymol.
438, 77 (2008),
Abstract;
A burst of auxilin recruitment determines the onset of clathrin-coated vesicle uncoating: R.H. Massol, et al.; PNAS
103, 10265 (2006),
Abstract;
Full Text
Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation: S.R. Nankoe, et al.; Trends Cell Biol.
16, 607 (2006),
Abstract;
Dynasore, a cell-permeable inhibitor of dynamin: E. Macia, et al. ; Dev. Cell
10, 839 (2006),
Abstract;
Identification of alkylidene hydrazides as glucagon receptor antagonists: A. Ling, et al.; J. Med. Chem.
44, 3141 (2001),
Abstract;
