Replaces Prod. #: BML-EI179
Compound 48/80 is an oligomeric mixture of condensation products of N-methyl-p-methoxyphenethylamine and formaldehyde. It activates G proteins by a mechanism analogous to that of mastoparan. It inhibits calmodulin and human platelet PLC and exhibits a concentration dependent biphasic modulation of human platelet PLA2.
Product Details
| Formula: | C32H46N3O3 . 3HCl |
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| MW: | 520.7 . 109.4 |
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| CAS: | 94724-12-6 |
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| Identity: | Determined by 1H-NMR. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (100mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stock solutions are stable for up to 3 months when stored at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
In Silico Modeling of Liver Metabolism in a Human Disease Reveals a Key Enzyme for Histidine and Histamine Homeostasis: R. Pagliarini, et al.; Cell. Rep.
15, 2292 (2016),
Application(s): Determined histamine-mediated skin permeability,
Abstract;
Anti-inflammatory and antinociceptive activity of ouabain in mice: D.I. de Vasconcelos, et al.; Mediators Inflamm.
2011, 912925 (2011),
Abstract;
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Activation of the Na+/K(+)-pump in rat peritoneal mast cells following histamine release: a possible role in cell recovery: T. Knudsen, et al.; Br. J. Pharmacol.
108, 120 (1993),
Abstract;
Eclosion hormone activates phosphatidylinositol hydrolysis in silkworm abdominal ganglia during adult metamorphosis: Y. Shibanaka, et al.; Eur. J. Biochem.
211, 427 (1993),
Abstract;
ADP-ribosylation of rho proteins is inhibited by melittin, mast cell degranulating peptide and compound 48/80: G. Koch, et al.; Eur. J. Pharmacol.
226, 87 (1992),
Abstract;
Biscoclaurine alkaloids inhibit receptor-mediated phospholipase A2 activation probably through uncoupling of a GTP-binding protein from the enzyme in rat peritoneal mast cells: S. Akiba, et al.; Biochem. Pharmacol.
44, 45 (1992),
Abstract;
Phosphorylation of smg p21B in rat peritoneal mast cells in association with histamine release inhibition by dibutyryl-cAMP: K. Izushi, et al.; FEBS Lett.
314, 241 (1992),
Abstract;
Activation of bovine rod outer segment phosphatidylinositol-4,5- bisphosphate phospholipase C by calmodulin antagonists does not depend on calmodulin: B.D. Gehm, et al.; Biochemistry
30, 11302 (1991),
Abstract;
Direct activation of GTP-binding regulatory proteins (G-proteins) by substance P and compound 48/80: M. Mousli et al.; FEBS Lett.
259, 260 (1990),
Abstract;
Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity: T. Higashijima et al.; J. Biol. Chem.
265, 14176 (1990),
Abstract;
Compound 48/80 is a potent inhibitor of phospholipase C and a dual modulator of phospholipase A2 from human platelet: C. Bronner et al.; Biochim. Biophys. Acta
920, 301 (1987),
Abstract;
Comparison of the calmodulin antagonists compound 48/80 and calmidazolium: K. Gietzen; Biochem. J.
216, 611 (1983),
Abstract;
Compound 48/80 is a selective and powerful inhibitor of calmodulin-regulated functions: K. Gietzen et al.; Biochim. Biophys. Acta
736, 109 (1983),
Abstract;
