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Orexin receptor 2 polyclonal antibody

BML-SA647-0050 50 µl 398.00 USD
BML-SA647-0200 200 µl 616.00 USD
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Product Details

Alternative Name:OX2R
Immunogen:Synthetic peptide corresponding to aa 391-405 of rat OX2R (orexin receptor 2).
UniProt ID:P56719
Species reactivity:Human, Mouse, Rat
Applications:ICC, IHC, WB
Recommended Dilutions/Conditions:Western Blot: Rat/Mouse brain lysate (1:400); Human colon cancer cell lines (1:200)
Immunohistochemistry: Rat small intestine section (paraffin embedded (1:50))
Immunocytochemistry: Human colon cancer cell line Colo-205 (1:500)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Purity Detail:Affinity purified on immobilized antigen.
Formulation:Lyophilized. After reconstitution, contains PBS, pH 7.4, 1% BSA and 0.025% sodium azide.
Reconstitution:Reconstitute with 50 µl or 200 µl dd-H2O pending sample size purchased.
Handling:Avoid freeze/thaw of reconstituted product.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:OX2R is one of two receptors that recognize the peptide neurotransmitters orexin A and orexin B. Orexin A and B are 33 and 28 amino acids in length, respectively, and are derived from a common precursor, prepro-orexin. OX1R binds orexin A with ten-fold greater affinity than to orexin B. OX2R binds both ligands with similar affinities. Both OX1R and OX2R belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. OX2R is thought to transmit signals through the Ga11 class of G proteins, resulting in the activation of phospholipase C with subsequent triggering of the phosphatidylinositol cascade and an influx of extracellular Ca2+, probably through transient receptor potential (TRP) channels. The orexin system has been shown to be involved in the regulation of sleep and wakefulness states and OX1R knockout mice show defects in the regulation of REM sleep, among other phenotypic alterations. In addition, the orexin system is involved in regulating autonomic functions such as blood pressure and heart rate, as well as in mechanisms that regulate the reward response in the brain. OX2R is expressed in both the central nervous system and peripheral locations such as gastrointestinal tissues, pancreas, and testis.
Regulatory Status:RUO - Research Use Only

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