Product Specification
| Alternative Name: | Intelectin-1, Intestinal lactoferrin receptor, Galactofuranose-binding lectin, Endothelial lectin HL-1 |
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| Clone: | Saly-1 |
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| Host: | Mouse |
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| Isotype: | IgG2b |
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| Immunogen: | Recombinant human omentin 1 (intelectin-1) (aa 17-231). |
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| UniProt ID: | Q8WWA0 |
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| Source: | Purified from concentrated hybridoma tissue cell culture supernatant. |
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| Species reactivity: | Human
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| Applications: | ELISA, IHC (PS), WB
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| Recommended Dilutions/Conditions: | ELISA (capture)
Western Blot (1:1,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Purity Detail: | Protein G-affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. |
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| Handling: | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -20°C. |
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| Shipping: | Shipped on Blue Ice |
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| Short Term Storage: | +4°C |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Omentin 1 (also named intelectin-1, endothelial lectin HL-1 and intestinal lactoferrin receptor) has been identified as a visceral fat (or omental fat) depot-specific adipokine. Omentin 1 is a secreted protein of ~38 kDa containing a fibrinogen-related domain. Omentin 1 is highly expressed in the omental fat, and much less in intestine, lung and heart. Addition of recombinant omentin in vitro did not affect basal, but enhanced insulin-stimulated glucose uptake in subcutaneous as well as in omental human adipocytes. Omentin 1 triggers AKT signalling in the absence of insulin. |
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| Regulatory Status: | RUO - Research Use Only |
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Figure: Immunohistochemical staining of endogenous human Omentin 1 in different human tissues (paraffin sections) using MAb to Omentin 1 (Saly-1) (Prod. No.
ALX-804-850).
Method: Different human normal tissues (A: Rectum; B: Small Intestine; C: Stomach) or cancer tissues (D: Colorectal cancer) were stained with MAb to Omentin 1 (Saly-1) by standard immunohistochemistry.
Pictures courtesy of Human Protein Atlas (www.proteinatlas.org)."
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Product Literature References
Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose: B.K. Tan, et al.; Diabetes
57, 801 (2008),
Abstract;
General Literature References
Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action: R.Z. Yang, et al.; Am. J. Physiol. Endocrinol. Metab.
290, E1253 (2006),
Abstract;
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