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Protein synthesis inhibitor
ALX-350-149-C025 25 µg 201.00 USD
ALX-350-149-C100 100 µg 320.00 USD
ALX-350-149-C500 500 µg 1,187.00 USD
ALX-350-149-M001 1 mg 1,943.00 USD
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Tricyclic alkaloid hepatotoxin. Exhibits a completely different mechanism of toxicity than microcystins. Protein synthesis inhibitor. Might be carcinogenic. Inhibits pyrimidine nucleotide synthesis.

Product Details

Source:Isolated from Cylindrospermopsis raciborskii.
Purity:≥95% (HPLC)
Identity:Identity determined by MS.
Appearance:Glassy solid.
Solubility:Soluble in water, methanol or DMSO.
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

The cyanotoxin cylindrospermopsin slows down cell cycle progression and extends metaphase duration in immortalised human airway epithelial cells: J. Vennmann, et al.; Toxicon 209, 28 (2022), Abstract;
Treatment of cylindrospermopsin by hydroxyl and sulfate radicals: Does degradation equal detoxification?: M. Schneider, et al.; J. Hazard. Mater. 424, 127447 (2022), Abstract;
Influence of refrigeration and freezing in Microcystins and Cylindrospermopsin concentrations on fish muscle of tilapia (Oreochromis niloticus) and tench (Tinca tinca): L. Diez-Quijada, et al.; Food Chem. Toxicol. 158, 112673 (2021), Abstract;
Cylindrospermopsin induced changes in growth, toxin production and antioxidant response of Acutodesmus acuminatus and Microcystis aeruginosa under differing light and nitrogen conditions: M.A. Chia, et al.; Ecotoxicol. Environ. Saf. 142, 189 (2017), Abstract;
Intestinal transport of Cylindrospermopsin using the Caco-2 cell line: S. Pichardo; Toxicol. In Vitro 38, 142 (2017), Application(s): Creation of stock solution of CYN, Abstract;
Cyanotoxins at low doses induce apoptosis and inflammatory effects in murine brain cells: potential implications for neurodegenerative diseases: L. Takser, et al.; Toxicol. Rep. 3, 180 (2016), Application(s): Cell culture, Abstract;
Inability to detect free cylindrospermopsin in spiked aquatic organism extracts plausibly suggests protein binding: M. Esterhyuzen-Londt, et al.; Toxicon. 122, 89 (2016), Application(s): Cell culture, Abstract;
Oxidative stress responses in the animal model, Daphnia pulex exposed to a natural bloom extract versus artificial cyanotoxin mixtures: M. Esterhuizen-Londt, et al.; Aquat. Toxicol. 179, 151 (2016), Abstract;
Beneficial effects of vitamin E supplementation against the oxidative stress on Cylindrospermopsin-exposed tilapia (Oreochromis niloticus): R. Guzman-Guillen, et al.; Toxicon 104, 34 (2015), Abstract;
Cylindrospermopsin induces neurotoxicity in tilapia fish (Oreochromis niloticus) exposed to Aphanizomenon ovalisporum: R. Guzmán-Guillén, et al.; Aquat. Toxicol. 161C, 17 (2015), Abstract;
Effects of microcystin-LR, cylindrospermopsin and a microcystin-LR/cylindrospermopsin mixture on growth, oxidative stress and mineral content in lettuce plants (Lactuca sativa L.): M. Freitas, et al.; Ecotoxicol. Environ. Saf. 116, 59 (2015), Application(s): HPLC, Exposure to lettuce plants, Abstract;
Toxin Resistance in Aquatic Fungi Poses Environmentally Friendly Remediation Possibilities: A Study on the Growth Responses and Biosorption Potential of Mucor hiemalis EH5 against Cyanobacterial Toxins: E. Balsano, et al.; Int. J. Water Wastewater Treat. 1, (2015), Full Text
Cylindrospermopsin degradation in sediments - The role of temperature, redox conditions, and dissolved organic carbon: S. Klitzke & J. Fastner; Water Res. 46, 1549 (2012), Abstract;
Time-dependent histopathological changes induced in Tilapia (Oreochromis niloticus) after acute exposure to pure cylindrospermopsin by oral and intraperitoneal route: D. Gutierrez-Praena, et al.; Ecotoxicol. Environ. Saf. 76, 102 (2012), Abstract;
Acute effects of pure cylindrospermopsin on the activity and transcription of antioxidant enzymes in tilapia (Oreochromis niloticus) exposed by gavage: M. Puerto, et al.; Ecotoxicology 20, 1852 (2011), Abstract;
Modulation of gap-junctional intercellular communication by a series of cyanobacterial samples from nature and laboratory cultures: K. Novakova, et al.; Toxicon 58, 76 (2011), Abstract;
Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts--indications of novel tumor-promoting cyanotoxins?: L. Blaha, et al.; Toxicon 55, 126 (2010), Abstract; Full Text
The cyanobacterial toxin cylindrospermopsin inhibits pyrimidine nucleotide synthesis and alters cholesterol distribution in mice: M. Reisner, et al.; Toxicol. Sci. 82, 620 (2004), Abstract;
The Palm Island mystery disease 20 years on: a review of research on the cyanotoxin cylindrospermopsin: D.J. Griffiths and M.L. Saker; Environ. Toxicol. 18, 78 (2003), Review, Abstract;
Preliminary evidence for in vivo tumour initiation by oral administration of extracts of the blue-green alga cylindrospermopsis raciborskii containing the toxin cylindrospermopsin: I.R. Falconer & A.R. Humpage; Environ. Toxicol. 16, 192 (2001), Abstract;
Cylindrospermopsin, a cyanobacterial alkaloid: evaluation of its toxicologic activity: G.R. Shaw, et al.; Ther. Drug Monit. 22, 89 (2000), Abstract;
Isolation and toxicity of Cylindrospermopsis raciborskii from an ornamental lake: P.R. Hawkins, et al.; Toxicon. 35, 341 (1997), Abstract;
Cylindrospermopsin, a potent hepatotoxin from the blue-green alga Cylindrospermopsis raciborskii: I. Ohtani, et al.; JACS 114, 7941 (1992), Full Text
Severe hepatotoxicity caused by the tropical cyanobacterium (blue-green alga) Cylindrospermopsis raciborskii (Woloszynska) Seenaya and Subba Raju isolated from a domestic water supply reservoir: P.R. Hawkins, et al.; Appl. Environ. Microbiol. 50, 1292 (1985), Abstract; Full Text

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